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Titolo:
Different effects of antipsychotic drugs on insulin release in vitro
Autore:
Melkersson, K; Khan, A; Hilding, A; Hulting, AL;
Indirizzi:
St Gorans Univ Hosp, Dept Psychiat, Stockholm, Sweden St Gorans Univ HospStockholm Sweden , Dept Psychiat, Stockholm, Sweden Karolinska Hosp, Dept Endocrinol & Diabetol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 etol, S-10401 Stockholm, Sweden
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 327 - 332
SICI:
0924-977X(200110)11:5<327:DEOADO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEIGHT-GAIN; OLANZAPINE; CLOZAPINE; SCHIZOPHRENIA; PSYCHOSES; LEPTIN;
Keywords:
antipsychotic agents; clozapine; insulin; weight gain; diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hulting, AL St Gorans Univ Hosp, Dept Psychiat, Stockholm, Sweden St Gorans Univ Hosp Stockholm Sweden iat, Stockholm, Sweden
Citazione:
K. Melkersson et al., "Different effects of antipsychotic drugs on insulin release in vitro", EUR NEUROPS, 11(5), 2001, pp. 327-332

Abstract

The aim of this study was to examine the influence of antipsychotic drugs on insulin release from pancreatic beta cells in vitro. The effect of sevenantipsychotics (i.e. chlorpromazine. haloperidol, perphenazine, zuclopenthixol, clozapine, olanzapine and risperidone) in a concentration of 10(-6) Mwas investigated on basal and glucose-stimulated insulin release. Clozapine increased basal insulin release, whereas haloperidol inhibited glucose-stimulated release and the other five antipsychotics had no significant effects. A possible stimulatory effect of clozapine on insulin release may explain its ability to increase appetite and induce weight gain. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:40:35