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Titolo:
Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions
Autore:
Myhrer, T; Andersen, JM;
Indirizzi:
Norwegian Def Res Estab, Div Protect & Mat, N-2027 Kjeller, Norway Norwegian Def Res Estab Kjeller Norway N-2027 at, N-2027 Kjeller, Norway
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 428, anno: 2001,
pagine: 323 - 330
SICI:
0014-2999(20011012)428:3<323:IWVMIR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; DISCRIMINATION TASK; ENTORHINAL CORTEX; D-CYCLOSERINE; HIPPOCAMPAL REGION; PERIRHINAL CORTEX; RECOGNITION MEMORY; SELECTIVE LESIONS; RHESUS-MONKEYS; ACQUISITION;
Keywords:
visual discrimination; NMDA receptor antagonist, functional; microinfusion; cortex, temporal; cortex, entorhinal; memory; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Myhrer, T Norwegian Def Res Estab, Div Protect & Mat, POB 25, N-2027 Kjeller, Norway Norwegian Def Res Estab POB 25 Kjeller Norway N-2027 er, Norway
Citazione:
T. Myhrer e J.M. Andersen, "Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions", EUR J PHARM, 428(3), 2001, pp. 323-330

Abstract

Results from lesion studies show that selective damage to the temporal cortex or lateral entorhinal cortex impairs visual memory, whereas damage to the hippocampal region does not affect retention of a visual discrimination task, Major input pathways of the above structures use glutamate as neurotransmitter. The glutamate NMDA receptor appears to play an important role for cognitive functions, The objective of the present study was to examine whether microinjections of the functional NMDA receptor antagonist, 3-amino-1-hydroxy-2-pyrrolidinone ((+)-HA-966), might result in effects mimicking those seen in lesion studies, The results show that infusion of HA-966 into the temporal cortex or lateral entorhinal cortex 1.5-3 h after the learning criterion had been obtained led to an impeded visual memory when tested 13 days later, whereas HA-966 infused into the hippocampal region did not affect memory. A similar retention deficit with HA-966 infusions in the temporal cortex or lateral entorhinal cortex was seen when testing took place 23 days later, whereas a markedly weaker effect was observed when the retentionperiod was reduced to 3 days. It is suggested that the hippocampal region is a temporary storing site for nonspatial memory engrams, and later posttraining memory consolidation involves the temporal and lateral entorhinal cortices. Furthermore, the degree of the effect of HA-966 is related to the length of the retention period. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:23:36