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Titolo:
Effects of subchronic lithium chloride treatment on G-protein subunits (G(olf) , G gamma(7)) and adenylyl cyclase expressed specifically in the rat striatum
Autore:
Miki, M; Hamamura, T; Ujike, H; Lee, YM; Habara, T; Kodama, M; Ohashi, K; Tanabe, Y; Kuroda, S;
Indirizzi:
Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Neuropsychiat, Okayama 7008558, Japan Zikei Hosp, Okayama 7028026, Japan Zikei Hosp Okayama Japan 7028026Zikei Hosp, Okayama 7028026, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 428, anno: 2001,
pagine: 303 - 309
SICI:
0014-2999(20011012)428:3<303:EOSLCT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM LITHIUM; D-AMPHETAMINE; WITHDRAWAL SYNDROME; CARBONATE TREATMENT; CEREBRAL-CORTEX; BRAIN REGIONS; MESSENGER-RNA; METHAMPHETAMINE; RECEPTOR; DISCONTINUATION;
Keywords:
lithium chloride; G(olf); striatum; G-gamma; adenylyl cyclase; relapse; manic-depressive illness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Hamamura, T Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8, Japan
Citazione:
M. Miki et al., "Effects of subchronic lithium chloride treatment on G-protein subunits (G(olf) , G gamma(7)) and adenylyl cyclase expressed specifically in the rat striatum", EUR J PHARM, 428(3), 2001, pp. 303-309

Abstract

Lithium salt has been widely used as a treatment for mania, but the mechanism of its effect remains unknown, Previously, by studying c-fos expression, we showed that the striatum was a possible target region for the antimanic effects of lithium salt. The present study focused on the effect of subchronic lithium chloride treatment on G-proteins (G(olf), G(gamma7)) and adenylyl cyclase type V, which are expressed specifically in the rat striatum. Subchronic lithium chloride treatment significantly increased the level of G(olf) protein, a stimulant alpha -subunit of G-protein, by 53.5% (P < 0.01), but the levels of G(gamma7) and adenylyl cyclase type V did not change. This increased level of G(olf) protein was found after 2 weeks of lithium chloride treatment, but not after 1 week, and the level returned to the basal level 1 week after withdrawal of lithium chloride. This result suggests that the level of G(olf) protein increases to compensate for the suppressionof the adenylyl cyclase system by lithium, and that this increase may account for the "rebound" phenomenon. which is the relapse observed after abrupt discontinuation of lithium salt treatment. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:29:02