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Titolo:
The organometallic approach to molecular diversity - Halogens as helpers
Autore:
Schlosser, M;
Indirizzi:
Univ Lausanne, BCh, Sect Chim, CH-1015 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1015 CH-1015 Lausanne, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 21, , anno: 2001,
pagine: 3975 - 3984
SICI:
1434-193X(200111):21<3975:TOATMD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SITE-SELECTIVE METALATION; DRUG DISCOVERY; DANCE REACTION; DIRECTED METALATION; ORGANIC-SYNTHESIS; SUBSTITUTION; DERIVATIVES; LITHIATION; THIOPHENES; CATALYSIS;
Keywords:
building blocks; combinatorial chemistry; controllable metalation site-selectivity; halogen shuffling; hydrogen protection; organofluorine compounds;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Schlosser, M Univ Lausanne, BCh, Sect Chim, CH-1015 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1015 nne, Switzerland
Citazione:
M. Schlosser, "The organometallic approach to molecular diversity - Halogens as helpers", EUR J ORG C, (21), 2001, pp. 3975-3984

Abstract

Strategies to functionalize simple, though structurally challenging, compounds in regiodivergent manner are outlined. The starting materials are inexpensive (5-500 epsilon /mol) arenes or heterocycles bearing heterosubstituents such as Cl, F, CF3, OCF3, and OCH3. A metal is introduced at the targeted position either by direct hydrogen/metal exchange or, if this is not feasible, by use of organometallic precursor species as relay stations. The derivatives thus produced are versatile intermediates that may be employed asbuilding blocks for further elaboration or even as scaffolds in combinatorial synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 19:32:30