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Titolo:
Richard B. Setlow, a commentary on seminal contributions and scientific controversies
Autore:
Cleaver, JE;
Indirizzi:
Univ Calif San Francisco, UCSF Canc Ctr, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
fascicolo: 2-3, volume: 38, anno: 2001,
pagine: 122 - 131
SICI:
0893-6692(2001)38:2-3<122:RBSACO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOBAL GENOMIC REPAIR; XERODERMA-PIGMENTOSUM VARIANT; TRANSCRIPTION-COUPLED REPAIR; NUCLEOTIDE EXCISION-REPAIR; STRAND BREAK REPAIR; DNA-REPAIR; HUMAN-CELLS; COCKAYNE-SYNDROME; HUMAN FIBROBLASTS; SELECTIVE REPAIR;
Keywords:
repair; aging; cancer; neurodegeneration; apoptosis; dinner;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Cleaver, JE Univ Calif San Francisco, UCSF Canc Ctr, Box 0808,Room N-431, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0808,Room N-431 San Francisco CA USA 94143
Citazione:
J.E. Cleaver, "Richard B. Setlow, a commentary on seminal contributions and scientific controversies", ENV MOL MUT, 38(2-3), 2001, pp. 122-131

Abstract

Richard B. Setlow inspired the field of DNA repair. His demonstration thatphotoproducts could be quantified within cells and their excision examinedexperimentally pioneered the identification of nucleotide excision repair. His early work was associated with the discovery of many founding phenomena of photobiology and DNA repair: the concept of excision repair itself, correlations between DNA repair, life span and aging, variations in repair among mammalian species, caffeine sensitization to UV damage, and the xeroderma pigmentosum (XP) repair deficiencies. We may now have mapped thoroughly the landscape of DNA repair that Dick helped open to exploration, but questions persist of how comprehensively we have explored all its canyons and mesas. Research into nontraditional species and kingdoms may yet provide unexpected surprises. The signal transduction pathways and mechanisms of DNA replication arrest in damaged mammalian cells remain a challenge. The importance of repair in vivo also provides many difficult research questions. One problem of current interest is the role of endogenous DNA damage and repairin human pathology, especially neurodegeneration exemplified by many XP patients. Cancer and neurodegeneration may represent converse responses of dividing and nondividing cells to mutagenic and lethal effects of DNA damaging agents. Cell death from endogenous oxidative DNA damage (apoptosis) may be antagonistic to malignant transformation in dividing cells but may cause neurodegeneration in nondividing neural tissue. Small reductions in the efficiency of repair, especially transcription-coupled repair, may overemphasize carcinogenesis in mice, while minimizing neurodegeneration, as compared to human patients. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:42:46