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Titolo:
Effects of chronic and acute methylphenidate hydrochloride (Ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3-to 11-day-old CD-1 mouse pups
Autore:
Penner, MR; McFadyen, MP; Carrey, N; Brown, RE;
Indirizzi:
Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4J1, Canada Dalhousie Univ Halifax NS Canada B3H 4J1 hol, Halifax, NS B3H 4J1, Canada Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 4J1, Canada Dalhousie UnivHalifax NS Canada B3H 4J1 iat, Halifax, NS B3H 4J1, Canada
Titolo Testata:
DEVELOPMENTAL PSYCHOBIOLOGY
fascicolo: 3, volume: 39, anno: 2001,
pagine: 216 - 228
SICI:
0012-1630(200111)39:3<216:EOCAAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; HUMAN BRAIN GROWTH; PSYCHOTROPIC MEDICATION; EXTRACELLULAR DOPAMINE; NUCLEUS-ACCUMBENS; D-AMPHETAMINE; DOUBLE-BLIND; RAT; CHILDREN;
Keywords:
Mus musculus; development; psychostimulant; ultrasonic vocalizations; Ritalin; attention deficit hyperactivity disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, RE Dalhousie Univ, Dept Psychol, Halifax, NS B3H 4J1, Canada Dalhousie Univ Halifax NS Canada B3H 4J1 ax, NS B3H 4J1, Canada
Citazione:
M.R. Penner et al., "Effects of chronic and acute methylphenidate hydrochloride (Ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3-to 11-day-old CD-1 mouse pups", DEVELOP PSY, 39(3), 2001, pp. 216-228

Abstract

The present study examined the effects of chronic and acute treatment withmethylphenidate hydrochloride (Ritalin) on isolation-induced ultrasonic vocalizations, spontaneous locomotor activity, and neuromotor coordination in3- to 11-day-old CD-1 mouse pups. In Experiment 1, 3- to 11-day-old pups received daily injections of saline, 5 mg/kg or 20 mg/kg of methylphenidate hydrochloride, or no injection and were tested on postnatal Days 3, 5, 7, 9, and 11. Both doses of methylphenidate resulted in significant increases in locomotor activity at all ages, but had no significant effect on body weight, neuromotor development, or emission of ultrasonic vocalizations. In Experiment 2, pups were given a single dose of methylphenidate (5 or 20 mg/kg), saline, or no injection on one of postnatal Days 5, 7, 9, or 11. This acute methylphenidate treatment increased locomotor activity but had no significant effects on ultrasonic vocalizations or neuromotor coordination. These results indicate that short-term, chronic methylphenidate treatment elevates locomotor responses, but has no immediate effects on anxiety like responses or on the development of neuromotor behavior of CD-1 mice in the first11 days of life. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:11:43