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Titolo:
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain
Autore:
Wichterle, H; Turnbull, DH; Nery, S; Fishell, G; Alvarez-Buylla, A;
Indirizzi:
Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA NYU New York NY USA 10016 kirball Inst Biomol Med, New York, NY 10016 USA Univ Calif San Francisco, Dept Neurosurg & Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 19, volume: 128, anno: 2001,
pagine: 3759 - 3771
SICI:
0950-1991(200110)128:19<3759:IUFMRD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CEREBRAL-CORTEX; MEDIAL GANGLIONIC EMINENCE; TANGENTIAL CELL DISPERSION; DEVELOPING HUMAN BRAIN; CORTICAL DEVELOPMENT; SUBVENTRICULAR ZONE; GABAERGIC NEURONS; INTERMEDIATE ZONE; EMBRYONIC BRAIN; NEURAL PLATE;
Keywords:
ganglionic eminences; neocortical development; tangential neuronal migration; ultrasound; fate map; nonpyramidal; interneurons; medium spiny neurons; GABA; parvalbumin; somatostatin; DARPP-32; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Alvarez-Buylla, A Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 USA
Citazione:
H. Wichterle et al., "In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain", DEVELOPMENT, 128(19), 2001, pp. 3759-3771

Abstract

Recent studies suggest that neurons born in the developing basal forebrainmigrate long distances perpendicularly to radial glia and that many of these cells reach the developing neocortex. This form of tangential migration,however, has not been demonstrated in vivo, and the sites of origin, pathways of migration and final destinations of these neurons in the postnatal brain are not fully understood. Using ultrasound-guided transplantation in utero, we have mapped the migratory pathways and fates of cells born in the lateral and medial ganglionic eminences (LGE and MGE) in 13.5-day-old mouseembryos. We demonstrate that LGE and MGE cells migrate along different routes to populate distinct regions in the developing brain. We show that LGE cells migrate ventrally and anteriorly, and give rise to the projecting medium spiny neurons in the striatum, nucleus accumbens and olfactory tubercle, and to granule and periglomerular cells in the olfactory bulb. By contrast, we show that the NIGE is a major source of neurons migrating dorsally and invading the developing neocortex. MGE cells migrate into the neocortex via the neocortical subventricular zone and differentiate into the transientsubpial granule neurons in the marginal zone and into a stable population of GABA-, parvalbumin- or somatostatin-expressing interneurons throughout the cortical plate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:38:25