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Titolo:
Kermit, frizzled interacting protein, regulates frizzled 3 signaling in neural crest development
Autore:
Tan, C; Deardorff, MA; Saint-Jeannet, JP; Yang, J; Arzoumanian, A; Klein, PS;
Indirizzi:
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Cell & Mol Biol Grp, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Biol Grp, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Anim Biol, Philadelphia, PA 19104 USA Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Med Inst, Philadelphia, PA 19104 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 19, volume: 128, anno: 2001,
pagine: 3665 - 3674
SICI:
0950-1991(200110)128:19<3665:KFIPRF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOMAIN-CONTAINING PROTEIN; TISSUE POLARITY; PDZ DOMAIN; VERTEBRATE DEVELOPMENT; XENOPUS-EMBRYOS; BETA-CATENIN; C-TERMINUS; WNT GENES; DROSOPHILA; WINGLESS;
Keywords:
Xenopus; frizzled; Wnt; Wnt1; frizzled 3; neural crest; PDZ domain; dishevelled; GIPC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Klein, PS Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Citazione:
C. Tan et al., "Kermit, frizzled interacting protein, regulates frizzled 3 signaling in neural crest development", DEVELOPMENT, 128(19), 2001, pp. 3665-3674

Abstract

Wnts are a family of secreted glycoproteins that are important for multiple steps in early development. Accumulating evidence suggests that frizzled genes encode receptors for Wnts. However, the mechanism through which frizzleds transduce a signal and the immediate downstream components that conveythat signal are unclear. We have identified a new protein, Kermit, that interacts specifically with the C-terminus of Xenopus frizzled-3 (Xfz3). Kermit is a 331 amino acid protein with a central PDZ domain. Kermit mRNA is expressed throughout Xenopus development and is localized to neural tissue ina pattern that overlaps Xfz3 expression temporally and spatially. Co-expression of Xfz3 and Kermit results in a dramatic translocation of Kermit to the plasma membrane. Inhibition of Kermit function with morpholino antisenseoligonucleotides directed against the 5 ' untranslated region of Kermit mRNA blocks neural crest induction by Xfz3, and this is rescued by co-injection of mRNA encoding the Kermit open reading frame. These observations suggest that Kermit is required for Wnt/frizzled signaling in neural crest development. To the best of our knowledge, Kermit is the first protein identified that interacts directly with the cytoplasmic portion of frizzleds to modulate their signaling activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:38:13