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Titolo:
A role for frizzled 3 in neural crest development
Autore:
Deardorff, MA; Tan, C; Saint-Jeannet, JP; Klein, PS;
Indirizzi:
Univ Penn, Sch Med, Cell & Mol Biol Grad Grp, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Grad Grp, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Med, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Anim Biol, Philadelphia, PA 19104 USA Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Med Inst, Philadelphia, PA 19104 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 19, volume: 128, anno: 2001,
pagine: 3655 - 3663
SICI:
0950-1991(200110)128:19<3655:ARFF3I>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
WNT SIGNALING PATHWAY; PROTO-ONCOGENE INT-1; XENOPUS-LAEVIS; MOUSE DEVELOPMENT; WNT/BETA-CATENIN; BETA-CATENIN; EXPRESSION; DROSOPHILA; MESODERM; WINGLESS;
Keywords:
Xenopus; Xwnt; frizzled; neural crest; Xfz3; slug; vertebrate embryo; melanocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Klein, PS Univ Penn, Sch Med, Cell & Mol Biol Grad Grp, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Citazione:
M.A. Deardorff et al., "A role for frizzled 3 in neural crest development", DEVELOPMENT, 128(19), 2001, pp. 3655-3663

Abstract

Wnts are a large family of secreted molecules implicated in numerous developmental processes. Frizzled proteins are likely receptors for Wnts and arerequired for Wnt signaling in invertebrates. A large number of vertebrate frizzled genes have also been identified, but their roles in mediating specific responses to endogenous Writs have not been well defined. Using a functional assay in Xenopus, we have performed a large screen to identify potential interactions between Wnts and frizzleds. We find that signaling by Xwnt1, but not other Wnts, can be specifically enhanced by frizzled 3 (Xfz3). As both Xfz3 and Xwnt1 are highly localized to dorsal neural tissues that give rise to neural crest, we examined whether Xfz3 mediates Xwnt1 signalingin the formation of neural crest. Xfz3 specifically induces neural crest in ectodermal explants and in embryos, similar to Xwnt1, and at lower levelsof expression, synergizes with Xwnt1 in neural crest induction. Furthermore, loss of Xfz3 function, either by depletion with a Xfz3-directed morpholino antisense oligonucleotide or by expression of an inhibitory form of Xfz3(NW), prevents Xwnt1-dependent neural crest induction in ectodermal explants and blocks neural crest formation in whole embryos. These results show that Xfz3 is required for Xwnt1 signaling in the formation of the neural crest in the developing vertebrate embryo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:41:11