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Titolo:
Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor
Autore:
Sakharova, OV; Taal, MW; Brenner, BM;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Renal Div, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Dept Med,Renal Div, Boston, MA 02115 USA
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 727 - 738
SICI:
1062-4821(200111)10:6<727:PODNFO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL TUBULAR CELLS; FACTOR GENE-EXPRESSION; GLOMERULAR MESANGIAL CELLS; PLASMINOGEN-ACTIVATOR INHIBITOR-1; PROGRESSIVE RENAL-DISEASE; TGF-BETA-1 MESSENGER-RNA; MATRIX PROTEIN-SYNTHESIS; TGF-BETA; ANGIOTENSIN-II; HIGH GLUCOSE;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Sakharova, OV Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,RenalDiv, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St BostonMA USA 02115 MA 02115 USA
Citazione:
O.V. Sakharova et al., "Pathogenesis of diabetic nephropathy: focus on transforming growth factor-beta and connective tissue growth factor", CURR OP NEP, 10(6), 2001, pp. 727-738

Abstract

Although considerable improvement in the prognosis of diabetic nephropathyhas been achieved in recent years due to intensive insulin and angiotensin-converting enzyme inhibitor treatment, these approaches do not provide complete protection against progression of diabetic nephropathy. An urgent need for additional novel therapies to prevent or further slow the progressionof diabetic nephropathy motivated us to provide an up-to-date review with particular emphasis on the potential role of two growth factors - transforming growth factor-beta and connective tissue growth factor - in the pathogenesis of diabetic nephropathy. The most intensively studied to date, transforming growth factor-beta appears to play a central role in the pathogenesis of diabetic nephropathy. Recently, attention has focused on connective tissue growth factor, which mimics the biological activity of transforming growth factor-beta in profibrotic tissue formation. Thus, acting as a downstream mediator of the profibrotic activity of transforming growth factor-beta, connective tissue growth factor may constitute a more specific target forfuture antifibrotic therapies. Curr Opin Nephrol Hypertens 10:727-736. (C)2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:10:16