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Titolo:
Parameters of glucose and lipid metabolism in the male Gottingen minipig: Influence of age, body weight, and breeding family
Autore:
Larsen, MH; Rolin, B; Wilken, M; Carr, RD; Svendsen, O; Bollen, P;
Indirizzi:
Novo Nordisk AS, Dept Pharmacol Res 1, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 1, DK-2880 Bagsvaerd, Denmark Royal Vet & Agr Univ, Dept Pharmacol & Pathobiol, Copenhagen, Denmark Royal Vet & Agr Univ Copenhagen Denmark Pathobiol, Copenhagen, Denmark Novo Nordisk AS, Dept Assay & Cell Technol, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 ol, DK-2880 Bagsvaerd, Denmark Ellegaard Gottingen Minipigs ApS, Dalmose, Denmark Ellegaard Gottingen Minipigs ApS Dalmose Denmark ApS, Dalmose, Denmark
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 5, volume: 51, anno: 2001,
pagine: 436 - 442
SICI:
1532-0820(200110)51:5<436:POGALM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL CHEMICAL VALUES; PLASMA LEPTIN; SERUM FRUCTOSAMINE; DIABETES-MELLITUS; CELL-POPULATIONS; OBESE GENE; INSULIN; CHOLESTEROL; PIGS; LIPOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Larsen, MH Novo Nordisk AS, Dept Pharmacol Res 1, 1Q1-28,Novo Alle, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS 1Q1-28,Novo Alle Bagsvaerd Denmark DK-2880 ark
Citazione:
M.H. Larsen et al., "Parameters of glucose and lipid metabolism in the male Gottingen minipig: Influence of age, body weight, and breeding family", COMPAR MED, 51(5), 2001, pp. 436-442

Abstract

The pig is useful as a model for human physiology and pathophysiology and could be an important supplement to the many available rodent models of diabetes mellitus. Due to their small size, Gottingen minipigs are especially suitable for long-term studies. The aim of the study reported here was to establish reference values for a range of glucose and lipid homeostasis parameters of interest that could be used to identify possible diabetes-prone male Gottingen minipig individuals, families, or age groups. Plasma samples from nonfed animals were analyzed for glucose, leptin, fructosamine, insulin, C-peptide, triglyceride, free fatty acids, and total cholesterol values. Breeding family had significant effects only on plasma triglyceride concentrations (P<0.001). Plasma concentrations of glucose (P=0.012), fructosamine (P<0.001) and triglycerides (P<0.001) increased significantly with age, whereas total cholesterol concentration decreased significantly (P=0.001) with age. Age did not influence other parameters. In conclusion, glycemia and insulinemia increased with age and body weight, possibly indicating a small deterioration in insulin sensitivity with age. It is, therefore, hypothesized that older, compared to younger animals may be more useful in the development of a model of type-2 diabetes mellitus. Furthermore, on the basis of decrease in cholesterol concentration with age, animals fed ad libitum with possibly a high calorie diet might be even more useful in the development of a type-2 diabetes mellitus model.

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Documento generato il 25/01/20 alle ore 15:51:54