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Titolo:
Use of genetically modified mouse models for evaluation of carcinogenic risk: Considerations for the laboratory animal scientist
Autore:
Recio, L; Everitt, J;
Indirizzi:
Chem Ind Inst Toxicol, Ctr Hlth Res, Res Triangle Pk, NC 27709 USA Chem Ind Inst Toxicol Res Triangle Pk NC USA 27709 angle Pk, NC 27709 USA
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 5, volume: 51, anno: 2001,
pagine: 399 - 405
SICI:
1532-0820(200110)51:5<399:UOGMMM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
V-HA-RAS; TRANSGENIC TG.AC MICE; XPA-DEFICIENT MICE; TUMOR-DEVELOPMENT; GENE; MUTATIONS; INDUCTION; SKIN; P53; TUMORIGENESIS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Recio, L Chem Ind Inst Toxicol, Ctr Hlth Res, POB 12137,6 Davis Dr, Res Triangle Pk, NC 27709 USA Chem Ind Inst Toxicol POB 12137,6 Davis Dr Res Triangle Pk NC USA 27709
Citazione:
L. Recio e J. Everitt, "Use of genetically modified mouse models for evaluation of carcinogenic risk: Considerations for the laboratory animal scientist", COMPAR MED, 51(5), 2001, pp. 399-405

Abstract

There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse oncogenicity bioassay. In this overview we will review the GM mouse models that have been proposed as bioassay alternatives and present some of the key laboratory animal science challenges that need to be considered when using these unique animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:31