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Titolo:
Comparative efficacy and tolerability of drug treatments for bipolar disorder
Autore:
Strakowski, SM; DelBello, MP; Adler, CM;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Disorders Res Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Program, Cincinnati, OH 45267 USA
Titolo Testata:
CNS DRUGS
fascicolo: 9, volume: 15, anno: 2001,
pagine: 701 - 718
SICI:
1172-7047(2001)15:9<701:CEATOD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HYPERAMMONEMIC ENCEPHALOPATHY; RANDOMIZED CONTROLLED TRIAL; POLYCYSTIC-OVARY-SYNDROME; MANIC-DEPRESSIVE ILLNESS; CLINICAL CASE SERIES; DOUBLE-BLIND; LITHIUM-CARBONATE; MOOD DISORDERS; ATYPICAL ANTIPSYCHOTICS; LAMOTRIGINE TREATMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Strakowski, SM Univ Cincinnati, Coll Med, Dept Psychiat, Disorders Res Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 nati, OH 45267 USA
Citazione:
S.M. Strakowski et al., "Comparative efficacy and tolerability of drug treatments for bipolar disorder", CNS DRUGS, 15(9), 2001, pp. 701-718

Abstract

Lithium has been the backbone of treatment for bipolar disorder for several decades, although recent advances have identified a number of other medications that have efficacy in treating various phases of the illness. These include the antiepileptic drugs valproate semisodium (divalproex sodium) and carbamazepine and some new antiepileptic drugs (e.g. lamotrigine and topiramate), and the atypical antipsychotics (e.g. olanzapine, clozapine and risperidone). Conventional antipsychotics continue to be used frequently in bipolar disorder, although they may be somewhat less effective than other treatments. Otherwise, to date, none of these treatments have been shown to be consistently more effective than any other, so that drug adverse effects and tolerability often dictate which agents are used in an individual patient. Drugs commonly used for the treatment of bipolar disorder are generally tolerated by most patients in large samples. However, the unique adverse effect signature of a drug will often suggest that it will be less tolerable insome patients than in others. Identifying a specific treatment for a specific patient requires a careful individualised assessment of the risk of adverse effects for that patient's unique circumstances.

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Documento generato il 24/01/20 alle ore 16:04:56