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Titolo:
Can anticonvulsant drug therapy 'cure' epilepsy?
Autore:
Eadie, MJ;
Indirizzi:
Univ Queensland, Dept Med, Brisbane, Qld, Australia Univ Queensland Brisbane Qld Australia ept Med, Brisbane, Qld, Australia
Titolo Testata:
CNS DRUGS
fascicolo: 9, volume: 15, anno: 2001,
pagine: 679 - 690
SICI:
1172-7047(2001)15:9<679:CADT'E>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL GENERAL-PRACTICE; ANTIEPILEPTIC DRUGS; CHILDHOOD EPILEPSY; SEIZURE TYPES; FOLLOW-UP; CHILDREN; PROGNOSIS; DISCONTINUATION; POPULATION; REMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Eadie, MJ 4th Floor,131 Wickham Tce, Brisbane, Qld 4000, Australia 4th Floor,131 Wickham Tce Brisbane Qld Australia 4000 Australia
Citazione:
M.J. Eadie, "Can anticonvulsant drug therapy 'cure' epilepsy?", CNS DRUGS, 15(9), 2001, pp. 679-690

Abstract

There is now evidence to show that, as time passes, epilepsy, even if untreated, tends to undergo spontaneous remission in a significant proportion of patients. The question therefore arises as to whether anticonvulsant drugtherapy increases this chance of the patient with epilepsy ultimately entering a terminal remission which continues after the treatment is withdrawn,Le. whether anticonvulsant drug therapy itself may sometimes cure epilepsy. There are no well-designed studies available in the literature that provide a clear answer to this question. However, data from a number of investigations carried out for other purposes can be used to see whether contemporary anticonvulsant drug therapy is associated with higher rates of expected untreated terminal remission than those that apply for never-treated patients with epilepsy, or for those whose anticonvulsant treatment has probably been inadequate for various social or historical reasons. Despite the admitted uncertainties inherent in drawing conclusions from such material, there appears to be a reasonably consistent tendency for contemporary anticonvulsant drug treatment to be associated with a greater chance of achieving probable cure of epilepsy. Therefore it would appear premature to take the view that contemporary anticonvulsant drug therapy does no more than suppress epileptic seizures until epilepsy remits spontaneously, or fails to remit, with the passing of time.

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Documento generato il 27/05/20 alle ore 15:41:33