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Titolo:
Recognition of multiple classes of hepatitis C antibodies increases detection sensitivity in oral fluid
Autore:
Zmuda, JF; Wagoneer, B; Liotta, L; Whiteley, G;
Indirizzi:
Immunomatrix Inc, Gaithersburg, MD 20878 USA Immunomatrix Inc Gaithersburg MD USA 20878 nc, Gaithersburg, MD 20878 USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 6, volume: 8, anno: 2001,
pagine: 1267 - 1270
SICI:
1071-412X(200111)8:6<1267:ROMCOH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALIVA; VIRUS; SERUM; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Zmuda, JF Immunomatrix Inc, Gaithersburg, MD 20878 USA Immunomatrix Inc Gaithersburg MD USA 20878 rsburg, MD 20878 USA
Citazione:
J.F. Zmuda et al., "Recognition of multiple classes of hepatitis C antibodies increases detection sensitivity in oral fluid", CL DIAG LAB, 8(6), 2001, pp. 1267-1270

Abstract

Paired serum-oral fluid samples from 1.27 hepatitis C virus (HCV)-positiveand 31 HCV-negative patients were tested for the presence of anti-HCV using the Ortho HCV 3.0 ELISA. Using the immunoglobulin G (IgG)-specific detection antibody provided with the HCV 3.0 ELISA we attained 100% sensitivity and specificity with serum samples; however, sensitivity in oral fluid samples was only 81%. By modifying the HCV 3.0 ELISA to utilize a secondary antibody cocktail that recognizes not only IgG but IgA and IgM as well, we attained 100% specificity and sensitivity with oral fluid samples.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:25:29