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Titolo:
The Arp2/3 complex: a central regulator of the actin cytoskeleton
Autore:
May, RC;
Indirizzi:
Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 11, volume: 58, anno: 2001,
pagine: 1607 - 1626
SICI:
1420-682X(200110)58:11<1607:TACACR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
WISKOTT-ALDRICH-SYNDROME; SYNDROME PROTEIN WASP; YEAST SACCHAROMYCES-CEREVISIAE; N-WASP; LISTERIA-MONOCYTOGENES; SHIGELLA-FLEXNERI; BINDING-PROTEIN; INTERACTING PROTEIN; ESCHERICHIA-COLI; FAMILY PROTEIN;
Keywords:
Arp2/3 complex; actin cytoskeleton; WASP; dendritic nucleation; Listeria;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: May, RC Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT ds, England
Citazione:
R.C. May, "The Arp2/3 complex: a central regulator of the actin cytoskeleton", CELL MOL L, 58(11), 2001, pp. 1607-1626

Abstract

In recent years the Arp2/3 complex has emerged as a central regulator of actin dynamics, assembling and cross-linking actin filaments to produce a diverse array of cellular structures. Here I discuss our current state of knowledge about this actin-remodelling machine. The predicted structure of theArp2/3 complex can be directly correlated with its ability to nucleate, cap and cross-link actin filaments. A growing family of Arp2/3 complex activators such as the WASP family, type I myosins, and the newly identified activators cortactin and Abp1p tightly regulate this activity within the cell. Localised activation of the Arp2/3 complex produces structures such as lamellipodia or actin patches via a process termed dendritic nucleation. Furthermore, several pathogenic microorganisms have evolved strategies to 'hijack' the Arp2/3 complex to their own advantage. Finally, I discuss some of thequestions which remain unanswered about this fascinating complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:56:30