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Titolo:
Effect of antidepressants on ATP-dependent calcium uptake by neuronal endoplasmic reticulum
Autore:
Couture, L; Elie, R; Lavoie, PA;
Indirizzi:
Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada Univ MontrealMontreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada
Titolo Testata:
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 11, volume: 79, anno: 2001,
pagine: 946 - 952
SICI:
0008-4212(200111)79:11<946:EOAOAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESYNAPTIC NERVE-TERMINALS; RAT HIPPOCAMPUS SYNAPTOSOMES; TRICYCLIC ANTIDEPRESSANTS; DEPRESSED-PATIENTS; SEQUESTRATION MECHANISM; CORTEX SYNAPTOSOMES; AFFECTIVE-DISORDERS; SECRETORY GRANULES; INTRACELLULAR CA2+; NA+-CA2+ EXCHANGE;
Keywords:
adenosine triphosphate-dependent calcium uptake; neuronal endoplasmic reticulum; lysed brain synaptosomes; tricyclic antidepressants; atypical antidepressants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Lavoie, PA Univ Montreal, Dept Pharmacol, CP 6128,Succ Centreville, Montreal, PQ H3C 3J7, Canada Univ Montreal CP 6128,Succ Centreville Montreal PQ Canada H3C 3J7
Citazione:
L. Couture et al., "Effect of antidepressants on ATP-dependent calcium uptake by neuronal endoplasmic reticulum", CAN J PHYSL, 79(11), 2001, pp. 946-952

Abstract

This study investigated the effect of tricyclic and atypical antidepressants on adenosine triphosphate (ATP) dependent calcium uptake by the endoplasmic reticulum of lysed synaptosomes from rat brain cortex. Tricyclic antidepressants (imipramine, desipramine, clomipramine, amitriptyline) exhibited no effect in the lower range (0.06 to 2 muM) of drug concentrations, and a concentration-dependent inhibition of calcium uptake in the upper range (6 to 200 muM). A concentration-dependent inhibition was observed for atypicalantidepressants (mianserin, desmethylmianserin, venlafaxine, desmethylvenlafaxine, fluoxetine) in both the lower and the upper range of drug concentrations. Since no stimulation of calcium uptake was observed in either concentration range, it appears that the tricyclic and atypical antidepressants tested are not capable of normalizing, through their effect on the endoplasmic reticulum, an overactive calcium signal, which is possibly implicated in the etiology of affective disorders. Also, although only marginal inhibition of calcium uptake is expected at brain concentrations of tricyclics andmianserin-desmethylmianserin that are likely to be encountered during clinical use, a more substantial inhibition could occur with fluoxetine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:29:04