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Titolo:
Pathogenesis of infectious diarrhea
Autore:
Stephen, J;
Indirizzi:
Univ Birmingham, Sch Biol Sci, Mol Microbiol & Cell Biol Grp, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
CANADIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 10, volume: 15, anno: 2001,
pagine: 669 - 683
SICI:
0835-7900(200110)15:10<669:POID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFICILE TOXIN-A; ENTEROPATHOGENIC ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM STRAINS; INTESTINAL EPITHELIAL-CELLS; YERSINIA YOP VIRULON; X-RAY-MICROANALYSIS; CLOSTRIDIUM-DIFFICILE; VIBRIO-CHOLERAE; CAMPYLOBACTER-JEJUNI; MURINE ROTAVIRUS;
Keywords:
diarrhea; Escherichia coli; Bibrio cholerae; Clostridium difficile; Shigella dysenteriae;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Stephen, J Univ Birmingham, Sch Biol Sci, Microbial Mol Genet & Cell Biol Grp, POB 363, Birmingham B15 2TT, W Midlands, England Univ Birmingham POB 363 Birmingham W Midlands England B15 2TT d
Citazione:
J. Stephen, "Pathogenesis of infectious diarrhea", CAN J GASTR, 15(10), 2001, pp. 669-683

Abstract

A brief overview of some of the main features involved in normal physiological bidirectional absorption and secretion of fluid in the gut is given, including the nature and cellular location of key enzymes, ion pumps, symports, antiports and diffusion channels; the microanatomy of intestinal villous vasculature and the dynamics of villus blood flow, which together generate hypertonic zones in villus tip regions; and the production, differentiation, escalator movement (from crypt to villus tip) and subsequent shedding of intestinal epithelial cells. (Neural and hormonal mechanisms that regulate normal mucosal ion transport are not discussed. ) The manner in which Vibrio cholerae, several pathotypes of Escherichia coli, several Salmonella serotypes, rotavirus, Campylobacter species, Shigella dysenteriae, Yersinia species and Clostridium difficile perturb these mechanisms and cause diarrhea, is discussed. Throughout the article, the main emphasis is on experimental studies designed to elucidate biological mechanisms and (where relevant) the microbial determinants responsible for diarrheal disease. Allusions arealso made to the involvement of host responses such as the inflammatory response, the production and release of potent cytokines and accelerated homeostatic responses (such as increased rates of crypt cell division seen in some infections), and the role that they play in pathophysiological fluid secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:39:09