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Titolo:
Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia
Autore:
Clausen, T; Djurovic, S; Henriksen, T;
Indirizzi:
Ulleval Univ Hosp, Dept Obstet & Gynaecol, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 tet & Gynaecol, N-0407 Oslo, Norway Aker Univ Hosp, Dept Obstet & Gynaecol, N-0407 Oslo, Norway Aker Univ Hosp Oslo Norway N-0407 Obstet & Gynaecol, N-0407 Oslo, Norway Ulleval Univ Hosp, Dept Med Genet, Oslo, Norway Ulleval Univ Hosp Oslo Norway l Univ Hosp, Dept Med Genet, Oslo, Norway Ulleval Univ Hosp, Inst Med Genet, Oslo, Norway Ulleval Univ Hosp Oslo Norway l Univ Hosp, Inst Med Genet, Oslo, Norway Univ Oslo, Natl Hosp, Dept Obstet & Gynaecol, Oslo, Norway Univ Oslo Oslo Norway , Natl Hosp, Dept Obstet & Gynaecol, Oslo, Norway
Titolo Testata:
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
fascicolo: 10, volume: 108, anno: 2001,
pagine: 1081 - 1087
SICI:
1470-0328(200110)108:10<1081:DIESTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; CORONARY HEART-DISEASE; FREE FATTY-ACIDS; NORMAL-PREGNANCY; SEVERE PREECLAMPSIA; INSULIN-RESISTANCE; LIPID-METABOLISM; RECURRENCE RISK; HYPERTRIGLYCERIDEMIA; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Clausen, T Ulleval Univ Hosp, Dept Obstet & Gynaecol, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 col, N-0407 Oslo, Norway
Citazione:
T. Clausen et al., "Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia", BR J OBST G, 108(10), 2001, pp. 1081-1087

Abstract

Objective To investigate whether hypertriglyceridemic dyslipidemia is a risk factor for either early or late onset pre-eclampsia. Design Prospective cohort study and nested case-control study. Setting Aker Hospital: a university hospital with all levels of obstetric care. Participants 2157 Caucasian pregnant women. Methods Blood samples were obtained from non-fasting subjects at 18 weeks of gestation. All samples were analysed for triglycerides, total-cholesterol, high density lipoproteins cholesterol and non-high density lipoproteins cholesterol. ApoB-100 were analysed in pre-eclamptic women and in 3:1 matched controls. The cohort data were analysed by multiple logistic regression and the case-control data by conditional logistic regression. Main outcome measures Adjusted odds ratios of early and late onset pre-eclampsia according to early second trimester serum concentration levels of lipids and ApoB-100. Results Eighteen women developed early onset pre-eclampsia and 53 women developed late onset pre-eclampsia. In the cohort model, women with triglycerides above 2.4 mmol/L had increased risk (OR 5. 1; 95% Cl 1.1-23.1) of early onset pre-eclampsia compared with those with triglycerides levels less than or equal to 1.5mmol/L. For women with high triglycerides: non-high density lipoproteins cholesterol ratios (> 90 centile) the OR (95% CI) for earlyonset pre-eclampsia was 7.1 (2.3-22.0) compared with those with low ratios(less than or equal to 50 centile). Similar associations were found in thecase control model. We found no associations between plasma lipids and risk of late onset pre-eclampsia. Conclusions Hypertriglyceridemic dyslipidemia before 20 weeks of gestationis associated with the risk of developing early but not late onset pre-eclampsia, giving support to the contention that these two variants of the disease are at least partly pathogenically different.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:24:40