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Titolo:
A randomized trial of the choice of treatment in prostate cancer: design and baseline characteristics
Autore:
Auvinen, A; Vornanen, T; Tammela, TLJ; Ala-Opas, M; Leppilahti, M; Salminen, P; Hakama, M;
Indirizzi:
Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland Univ Tampere Tampere Finland FIN-33014 Hlth, FIN-33014 Tampere, Finland Finnish Canc Registry, FIN-00170 Helsinki, Finland Finnish Canc Registry Helsinki Finland FIN-00170 00170 Helsinki, Finland Kymenlaakso Cent Hosp, Dept Surg, Kotka, Finland Kymenlaakso Cent Hosp Kotka Finland ent Hosp, Dept Surg, Kotka, Finland Tampere Univ Hosp, Dept Urol, Tampere, Finland Tampere Univ Hosp TampereFinland niv Hosp, Dept Urol, Tampere, Finland Kuopio Univ Hosp, Dept Urol, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 Urol, SF-70210 Kuopio, Finland Seinajoki Cent Hosp, Dept Surg, Seinajoki, Finland Seinajoki Cent Hosp Seinajoki Finland sp, Dept Surg, Seinajoki, Finland Kanta Hame Cent Hosp, Dept Surg, Hameenlinna, Finland Kanta Hame Cent Hosp Hameenlinna Finland ept Surg, Hameenlinna, Finland
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 7, volume: 88, anno: 2001,
pagine: 708 - 715
SICI:
1464-4096(200111)88:7<708:ARTOTC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; RADICAL PROSTATECTOMY; RADIOTHERAPY; COMPLICATIONS; INSTRUMENT; SYMPTOMS; QLQ-C30; MEN;
Keywords:
prostate neoplasms; quality of life; decision making; patient participation; randomised controlled trials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Auvinen, A Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland Univ Tampere Tampere Finland FIN-33014 33014 Tampere, Finland
Citazione:
A. Auvinen et al., "A randomized trial of the choice of treatment in prostate cancer: design and baseline characteristics", BJU INT, 88(7), 2001, pp. 708-715

Abstract

Objective To assess the effects of different approaches to decision-makingon the treatment chosen for prostate cancer and on the patients' quality of life in prostate cancer,Patients and methods A multicentre randomized trial was conducted. including all histologically confirmed cases of prostate cancer diagnosed between September 1993 and November 1994 in four Finnish hospitals. in the intervention group, the role of the patient in the choice of treatment was activelyemphasized. In the control group. the treatment was chosen using standardized treatment protocols. The first intermediate endpoint was the patient's participation in decisionmaking and the next will be the treatment chosen in the intervention and control groups. The main outcome will be the qualityof life. Clinical data on prognostic factors including age. tumour grade, stage, functional Status and serum prostate-specific antigen (PSA) concentration was collected for comparison between the arms, and between those enrolled or not. Results In all. 210 of 251 eligible patients were randomized into the two arms. Patients were randomized before obtaining informed consent. which ledto four patients already randomized refusing to participate. The 41 patients not enrolled were of similar age and grade distribution. but more frequently had extensive disease than had those enrolled in the trial. Three patients were unable to participate because of rapid deterioration in their general condition after randomization. There were no clear differences in baseline characteristics (including age, functional status. tumour grade and stage) of the patients between the arms. The distribution of PSA level differed slightly between the arms, which may require adjustment in the analyses. Patients in the intervention arm participated in decision-making more actively than those in the control arm. Conclusion Randomized studies on ethical issues such as the patient's rolein choosing treatment are feasible and likely to provide important information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:54:41