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Titolo:
Amygdala response to fearful faces in anxious and depressed children
Autore:
Thomas, KM; Drevets, WC; Dahl, RE; Ryan, ND; Birmaher, B; Eccard, CH; Axelson, D; Whalen, PJ; Casey, BJ;
Indirizzi:
Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, Dept Psychiat, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dept Psychiat, New York, NY 10021 USA NIMH, Mood & Anxiety Disorders Neuroimaging Sect, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 ders Neuroimaging Sect, Bethesda, MD 20892 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA rgh, Dept Psychiat, Pittsburgh, PA USA Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Psychiat, Madison, WI 53706 USA Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Psychol, Madison, WI 53706 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 11, volume: 58, anno: 2001,
pagine: 1057 - 1063
SICI:
0003-990X(200111)58:11<1057:ARTFFI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; EMOTIONAL FACIAL EXPRESSIONS; SYMPTOM PROVOCATION; MAJOR DEPRESSION; BRAIN ACTIVATION; RECOGNITION; ANXIETY; DAMAGE; FMRI; VOLUMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, KM Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, DeptPsychiat, 1300 York Ave,Box 140,Suite F-1332, New York, NY 10021 USA Cornell Univ 1300 York Ave,Box 140,Suite F-1332 New York NY USA 10021
Citazione:
K.M. Thomas et al., "Amygdala response to fearful faces in anxious and depressed children", ARCH G PSYC, 58(11), 2001, pp. 1057-1063

Abstract

Background: Alterations in amygdala function have been implicated in the pathophysiological characteristics of adult anxiety and depressive disorders. Studies with healthy adults and children, as well as with adults who haveamygdala lesions, have found facial expressions of emotion to be useful probes of amygdala activity. Our study examined the amygdala response to fearful and neutral facial expressions in healthy, anxious, and depressed children. We hypothesized that children with anxiety and depression may show atypical amygdala responses to emotional stimuli. Methods: Twelve children (8-16 years of age) with generalized anxiety or panic disorder and 12 healthy comparison children underwent noninvasive functional magnetic resonance imaging while viewing photographs of fearful and neutral facial expressions. In a second comparison, 5 girls with major depressive disorder were compared with 5 anxious and 5 healthy girls from the previous sample. Results: Children with anxiety disorders showed an exaggerated amygdala response to fearful faces compared with healthy children, whereas depressed children showed a blunted amygdala response to these faces. In addition, themagnitude of the amygdala's signal change between fearful and neutral faces was positively correlated with the severity of everyday anxiety symptoms. Conclusions: Our results suggest that amygdala function is affected in both anxiety and depression during childhood and adolescence. Moreover, this disruption appears to be specific to the child's own rating of everyday anxiety.

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Documento generato il 29/03/20 alle ore 12:11:22