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Titolo:
Epidermal growth factor receptor structure, regulation, mitogenic signalling and effects of activation
Autore:
Boulougouris, P; Elder, J;
Indirizzi:
Keele Univ, Acad Dept Surg, Stoke On Trent, Staffs, England Keele Univ Stoke On Trent Staffs England Stoke On Trent, Staffs, England
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4A, volume: 21, anno: 2001,
pagine: 2769 - 2775
SICI:
0250-7005(200107/08)21:4A<2769:EGFRSR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EGF-RECEPTOR; TYROSINE PHOSPHORYLATION; HUMAN FIBROBLASTS; ONCOGENE PROTEIN; NA+/H+ EXCHANGE; FACTOR-ALPHA; 3T3 CELLS; KINASE; EXPRESSION; A431-CELLS;
Keywords:
EGF, epidermal growth factor; TGF-alpha, transforming growth factor -alpha; EGFr, epidermal growth factor receptor dimerization, protein tyrosine kinases (PTK), autophosphorylation, signalling enzymes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Boulougouris, P FRCS, 5 Iokastis St,Zeo Zografou, Athens 15772, Greece FRCS 5 Iokastis St,Zeo Zografou Athens Greece 15772 reece
Citazione:
P. Boulougouris e J. Elder, "Epidermal growth factor receptor structure, regulation, mitogenic signalling and effects of activation", ANTICANC R, 21(4A), 2001, pp. 2769-2775

Abstract

The biological effects of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-a) are mediated by an interaction with a specific cell surface receptor having both intra- and extracellular domains. The structure of the intracellular domain can be closely aligned with retroviral protein tyrosine kinases. Upon ligand-binding there is a change in conformation of the extracellular domain, the receptor being converted to dimeric. Dimeric receptor has a higher rate of catalysis than monomeric and rapidly becomes phosphorylated. This form of the receptor now associates with and phosphorylates enzymes such as phospholipase-C altering their catalytic activity and subcellular distribution This system appears to stimulate the effects of epidermal growth factor receptor(EGFr) activation, notably proliferation, morphology, paracrine effects and differentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:24:30