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Titolo:
High expression of endogenous Bcl-2 and Bcl-xL in thymic lymphomas do not diminish their sensitivity to etoposide-induced apoptosis
Autore:
Matuszyk, J; Kalas, W; Cebrat, M; Strzadala, L;
Indirizzi:
Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland Polish Acad Sci Wroclaw Poland PL-53114 herapy, PL-53114 Wroclaw, Poland
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4A, volume: 21, anno: 2001,
pagine: 2677 - 2680
SICI:
0250-7005(200107/08)21:4A<2677:HEOEBA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TCR TRANSGENIC MICE; FAMILY PROTEINS; CYTOCHROME-C; THYMOCYTE APOPTOSIS; CELL-DEATH; T-CELLS; RESISTANCE; BCL-X(L); OVEREXPRESSION; MITOCHONDRIA;
Keywords:
thymic lymphoma; Bcl-2; Bcl-xL; etoposide; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Matuszyk, J Polish Acad Sci, Inst Immunol & Expt Therapy, Weigla 12, PL-53114 Wroclaw,Poland Polish Acad Sci Weigla 12 Wroclaw Poland PL-53114 claw,Poland
Citazione:
J. Matuszyk et al., "High expression of endogenous Bcl-2 and Bcl-xL in thymic lymphomas do not diminish their sensitivity to etoposide-induced apoptosis", ANTICANC R, 21(4A), 2001, pp. 2677-2680

Abstract

It was previously reported that thymic lymphomas of anti HY-TCR transgenicmice were resistant to ionomycin but were sensitive to 50 muM of etoposide. We selected lymphoma clones with strong expression of anti-apoptotic proteins Bcl-2 or Bcl-xL and found that in contrast to proteins encoded by exogenous genes in other model systems, over-expression of endogenous Bcl-2 andBcl-xL proteins failed to protect against etoposide-induced apoptosis. Susceptibility of lymphoma cells was not diminished even to suboptimal concentration of 0.5 muM of etoposide. Treatment with etoposide did not decrease the ratio of anti-apoptotic Bcl-2 and Bcl-xL proteins to pro-apoptotic Bax protein. Results presented here suggest that high expression of Bcl-2 and Bcl-xL may not diminish susceptibility of T-cell lymphomas to chemotherapy with etoposide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:03:18