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Titolo:
Transformation of rat fibroblasts by TGF-beta and EGF induces sensitivity for intercellular induction of apoptosis
Autore:
Haufel, T; Bauer, G;
Indirizzi:
Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Virol, D-79104 Freiburg, Germany
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4A, volume: 21, anno: 2001,
pagine: 2617 - 2628
SICI:
0250-7005(200107/08)21:4A<2617:TORFBT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; BARR VIRUS INDUCTION; MOLECULAR-WEIGHT COMPLEX; BENZOIC-ACID HYDRAZIDES; NORMAL-CELLS; SERUM FACTOR; INDUCED ELIMINATION; HYDROXYL RADICALS; BINDING-PROTEIN; HUMAN-PLATELETS;
Keywords:
TGF-beta; superoxide anion; reactive oxygen species; apoptosis; intercellular signalling; oncogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Bauer, G Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, Hermann Herder Str 11,D-79104 Freiburg, Germany Univ Freiburg Hermann Herder Str 11 Freiburg Germany D-79104 any
Citazione:
T. Haufel e G. Bauer, "Transformation of rat fibroblasts by TGF-beta and EGF induces sensitivity for intercellular induction of apoptosis", ANTICANC R, 21(4A), 2001, pp. 2617-2628

Abstract

During intercellular induction of apoptosis, TGF-beta-treated nontransformed fibroblasts induce apoptosis specifically in transformed fibroblasts. Totest whether sensitivity to intercellular induction of apoptosis is causally related to the expression of the transformed phenotype, NRK 536 cells were reversibly transformed by TGF-beta / EGF- treatment and were tested for their sensitivity to intercellular induction of apoptosis. Cells that expressed the transformed phenotype after application of both cytokines exhibited sensitivity for intercellular induction of apoptosis, whereas cells treated with only one of the cytokines did not show the transformed phenotype and remained insensitive. Sensitivity to intercellular induction seems to be determined by extracellular generation of superoxide anions, as sensitive cells generated extracellular superoxide anions and intercellular induction of apoptosis in these cells was inhibited by SOD. These data demonstrated that the cytokine-determined transformed phenotype of fibroblasts controls their sensitivity for intercellular induction of apoptosis through inductionof superoxide anion generation.

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Documento generato il 21/09/20 alle ore 09:43:19