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Titolo:
Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer
Autore:
Schoppmann, SF; Birner, P; Studer, P; Breiteneder-Geleff, S;
Indirizzi:
Univ Vienna, Inst Clin Pathol, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 st Clin Pathol, A-1090 Vienna, Austria Int Clin Pathol, Basel, Switzerland Int Clin Pathol Basel SwitzerlandInt Clin Pathol, Basel, Switzerland
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4A, volume: 21, anno: 2001,
pagine: 2351 - 2355
SICI:
0250-7005(200107/08)21:4A<2351:LMDALI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR EPITHELIAL-CELLS; CERVICAL-CARCINOMA; TUMOR ANGIOGENESIS; NODE METASTASES; VESSEL INVASION; OVARIAN-CANCER; PROGNOSIS; GROWTH; PODOCALYXIN; MEMBRANE;
Keywords:
lymphatic microvessel density; lymphangiogenesis; lymphovascular invasion; breast cancer; lymph node metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schoppmann, SF Univ Vienna, Inst Clin Pathol, Waehringer Guertel 18, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18 Vienna Austria A-1090 ia
Citazione:
S.F. Schoppmann et al., "Lymphatic microvessel density and lymphovascular invasion assessed by anti-podoplanin immunostaining in human breast cancer", ANTICANC R, 21(4A), 2001, pp. 2351-2355

Abstract

Background: The development of an antibody against podoplanin has enabled us to selectively stain lymphatic vessels in breast cancer samples for the first time. Materials and Methods: We investigated lymphatic vessels in 45 specimens of invasive breast cancer by immunostaining for podoplanin. Lymphatic microvessel density (LMVD) was correlated with various clinical and histopathological parameters. LMVD was also compared to blood microvessel density (BMVD), assessed by CD34 -immunostaining. Results: LMVD as well as lymphovascular invasion (LVI) correlated significantly with the lymph node status (p=0.001/p=0.035). Logistic regression revealed that LVI was the more important factor for development of lymph node metastasis (p=0.043). There was no significant association between various clinical and histopathological parameters and LMVD or LVI, nor was a correlation found between LMVD and BMVD (p=0.121). Conclusion: High LMVD and the presence of LVI are strongly associated with lymph node metastasis in breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:41:36