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Titolo:
Prognostic parameters in carcinosarcomas of the uterus: A clinico-pathologic study
Autore:
Bodner-Adler, B; Bodner, K; Obermair, A; Czerwenka, K; Petru, E; Leodolter, S; Mayerhofer, K;
Indirizzi:
Univ Vienna, Dept Obstet & Gynecol, Sch Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 necol, Sch Med, A-1090 Vienna, Austria Univ Vienna, Dept Gynecopathol, Sch Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 athol, Sch Med, A-1090 Vienna, Austria Graz Univ, Dept Obstet & Gynecol, A-8010 Graz, Austria Graz Univ Graz Austria A-8010 ept Obstet & Gynecol, A-8010 Graz, Austria
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4B, volume: 21, anno: 2001,
pagine: 3069 - 3074
SICI:
0250-7005(200107/08)21:4B<3069:PPICOT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIXED MULLERIAN TUMORS; MESODERMAL TUMORS; UTERINE SARCOMAS; ADRIAMYCIN; ENDOMETRIUM; PATTERNS;
Keywords:
carcinosarcoma; uterus; prognostic parameters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mayerhofer, K Univ Vienna, Dept Obstet & Gynecol, Sch Med, Wahringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Guertel 18-20 Vienna Austria A-1090 a
Citazione:
B. Bodner-Adler et al., "Prognostic parameters in carcinosarcomas of the uterus: A clinico-pathologic study", ANTICANC R, 21(4B), 2001, pp. 3069-3074

Abstract

Background: Carcinosarcomas of the uterus are highly aggressive malignant neoplasms with early lymphatic and hematogenous spread. The most important prognostic factor in carcinosarcoma is the event of the tumor at the time of diagnosis. The prognostic impact of other factors such as myometrial invasion, menopausal age, age, parity and adjuvant therapy is still being discussed controversially. Materials and Methods: Nineteen patients with histologically proven carcinosarcoma were included in the analysis. The patients were staged according to a modification of the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer. For each patient, the histological material was reviewed by an experienced pathologist. Carcinosarcoma was defined histologically as any tumor of uterine origin composed of carcinomatous and sarcomatous components. Results: The median follow-up time was 91 months (25% quartile, 47 months; 75% quartile, 145 months). The median overall survival of the 19 patients was 59 months, resulting in a 5-year overall survival rate of 43%. Three out of the nineteen (16%) patients demonstrated progressive disease while 6 out of 10 (32%) patients developed recurrent disease with a median disease free survival of16 months (range 8-54). Eleven out of nineteen (58%) patients died of the disease. A univariate model revealed that early tumor stage (stage 1) (p < 0.023), low myometrial invasion (p < 0.017) and late onset of the menopause(p < 0.050) were significantly associated with a lengthened overall survival in patients with carcinosarcoma. Age (p = 0.34), parity (p = 0.16) and adjuvant radiotherapy (p = 0.45) did not influence overall survival of patients with carcinosarcoma. Conclusion: Early tumor stage, low myometrial invasion and late onset of the menopause are associated with a lengthened overall survival in patients with carcinosarcoma.

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Documento generato il 27/09/20 alle ore 00:58:10