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Titolo:
Prognostic value of carcinoembryonic antigen (CEA) in tumor tissue of patients with colorectal cancer
Autore:
Nakagoe, T; Sawai, T; Tsuji, T; Ayabe, H; Nakazaki, T; Ishikawa, H; Hatano, K; Kajiwara, K; Miyashita, K; Matsuo, T; Nogawa, T; Arisawa, K;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 ept Surg 1, Nagasaki 8528501, Japan Nagasaki Saiseikai Hosp, Dept Surg, Nagasaki, Japan Nagasaki Saiseikai Hosp Nagasaki Japan Hosp, Dept Surg, Nagasaki, Japan Nagasaki Univ, Sch Med, Dept Prevent Med & Hlth Promot, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 lth Promot, Nagasaki 8528501, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 4B, volume: 21, anno: 2001,
pagine: 3031 - 3036
SICI:
0250-7005(200107/08)21:4B<3031:PVOCA(>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIALS; SERUM; CA-19-9; PLASMA;
Keywords:
colorectal cancer; tissue CEA; carcinoembryonic antigen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagoe, T Nagasaki Univ, Sch Med, Dept Surg 1, 1-7-1 Sakamoto, Nagasaki 8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 501, Japan
Citazione:
T. Nakagoe et al., "Prognostic value of carcinoembryonic antigen (CEA) in tumor tissue of patients with colorectal cancer", ANTICANC R, 21(4B), 2001, pp. 3031-3036

Abstract

To establish the prognostic value of carcinoembryonic antigen (CEA) concentration in tumor tissue (T-CEA), normal colonic mucosa (N-CEA) and pre-operative serum (S-CEA), we studied 79 patients who underwent resections for colorectal cancer. The patients were separated into groups reflecting laboratory values lower or higher than a diagnostic value (S-CEA) or the median value of the entire population (T-CEA, N-CEA). A high S-CEA predicted for more advanced stage (p=0.028), whereas no association was noted between stage and CEA concentration for T-CEA and N-CEA groups. ne high S-CEA and T-CEA groups had a worse clinical outcome (p=0.0036 and p=0.024, respectively), while survival of high versus low N-CEA groups did not differ. By Cox's regression analysis, high T-CEA concentration was an independent variable for poor outcome (Hazard ratio, 3.15), while S-CEA and N-CEA were not. In conclusion, a high T-CEA concentration was the only independent predictor of poor outcome after resection for colorectal cancer.

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Documento generato il 20/09/20 alle ore 07:37:57