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Titolo:
Sertraline-induced hypoglycemia
Autore:
Pollak, PT; Mukherjee, SD; Fraser, AD;
Indirizzi:
Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Coll Pharm, Halifax, NS B3H 2Y9, Canada Dalhousie Univ Halifax NS Canada B3H 2Y9 arm, Halifax, NS B3H 2Y9, Canada Dalhousie Univ, Dept Med, Queen Elizabeth II Hlt Sci Ctr, Halifax, NS, Canada Dalhousie Univ Halifax NS Canada eth II Hlt Sci Ctr, Halifax, NS, Canada Dalhousie Univ, Dept Pathol, Queen Elizabeth II Hlt Sci Ctr, Halifax, NS, Canada Dalhousie Univ Halifax NS Canada eth II Hlt Sci Ctr, Halifax, NS, Canada
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 11, volume: 35, anno: 2001,
pagine: 1371 - 1374
SICI:
1060-0280(200111)35:11<1371:SH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; FLUOXETINE; DEPRESSION; MICE;
Keywords:
drug-induced hypoglycemia; selective serotonin-reuptake inhibitor; sertraline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Pollak, PT Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Coll Pharm, Suite 409 Bethune Bldg, Halifax, NS B3H 2Y9, Canada Dalhousie Univ Suite 409 Bethune Bldg Halifax NS Canada B3H 2Y9
Citazione:
P.T. Pollak et al., "Sertraline-induced hypoglycemia", ANN PHARMAC, 35(11), 2001, pp. 1371-1374

Abstract

OBJECTIVE: To report a case of hypoglycemia that occurred in a patient treated with the selective serotonin-reuptake inhibitor, sertraline. CASE SUMMARY: An 82-year-old white woman with mild cardiovascular disease and no history of glucose intolerance was seen in the emergency department for a presyncopal episode associated with a blood glucose of 32 mg/dL as measured by the ambulance attendant. She had similar symptoms the day before. Despite repeated administration of oral and intravenous glucose, the patient had recurrent episodes of hypoglycemia and was hospitalized for four days. She had started taking sertraline 50 mg once daily for mild depression 25 days prior to presentation. Other medications included furosemide 20 mg/d, ramipril 5 mg/d, clopidogrel 75 mg/d, nitroglycerin patch 0.4 mg/h, and lorazepam 1 mg taken occasionally for agitation. She had never been prescribed any oral hypoglycemic agents. Serum sertraline and desmethylsertraline concentrations measured two, three, and four days after discontinuing sertraline were within the expected range, but the rate of decline was consistentwith a moderately prolonged half-time. DISCUSSION: Sertraline has been shown to blunt postprandial hyperglycemia in rats and to potentiate the hypoglycemic effects of sulfonylurea agents in humans. It has not been reported to cause hypoglycemia independently, butin this case, a nondiabetic patient experienced multiple episodes of hypoglycemia that resolved after discontinuation of sertraline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:54:27