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Titolo:
Pathogenic role of endothelin 1 in hemodynamic dysfunction in experimentalacute pulmonary thromboembolism
Autore:
Lee, JH; Chun, YG; Lee, IC; Tuder, RM; Hong, SB; Shim, TS; Lim, CM; Koh, Y; Kim, DS; Kim, WD; Lee, SD;
Indirizzi:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med,Div Pulm & Crit CareMed, Seoul, South Korea Univ Ulsan Seoul South Korea iv Pulm & Crit CareMed, Seoul, South Korea Asan Med Ctr, Dept Diagnost Pathol, Seoul, South Korea Asan Med Ctr Seoul South Korea Dept Diagnost Pathol, Seoul, South Korea Asan Life Sci Inst, Seoul, South Korea Asan Life Sci Inst Seoul South Korea Life Sci Inst, Seoul, South Korea Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Pathol, Denver, CO 80262 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 7, volume: 164, anno: 2001,
pagine: 1282 - 1287
SICI:
1073-449X(20011001)164:7<1282:PROE1I>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAS-EXCHANGE; AIR-EMBOLISM; HYPERTENSION; CELLS; MEDIATOR; DISEASE; RNA;
Keywords:
embolism; endothelin; hemodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SD Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med,Div Pulm & Crit CareMed, 388-1 Poongnab Dong, Seoul, South Korea Univ Ulsan 388-1 Poongnab Dong Seoul South Korea ul, South Korea
Citazione:
J.H. Lee et al., "Pathogenic role of endothelin 1 in hemodynamic dysfunction in experimentalacute pulmonary thromboembolism", AM J R CRIT, 164(7), 2001, pp. 1282-1287

Abstract

The plasma endothelin-1 (ET-1) level is elevated in patients with acute pulmonary thromboembolism (APE). Whether ET-1 is a pathogenic mediator or a simple marker of APE is not known. We investigated the role of ET-1 in hemodynamic dysfunction in APE through evaluating the effects of ETA receptor antagonist in an experimental APE model. We also examined ET-1 expression in embolized lungs. In a canine autologous blood clot pulmonary embolism model, ETA receptor antagonist ZD2574 (10 mg/kg, intravenous; ZD2574 group; n = 6) or vehicle (control group; n = 5) was administered. Hemodynamic and gas exchange parameters and plasma levels of ET-1 were serially measured. Prepro-ET-1 mRNA expression and the distribution of ET-1 peptide in lung tissueswere also examined. With ZD2574 pulmonary arterial pressure and pulmonary vascular resistance significantly decreased, and were lower compared with the control group. The decrease in cardiac output was also less in the ZD2574 group. Plasma ET-1 levels increased after embolization. Prepro-ET-1 mRNA expression increased in embolized lungs and ET-1 peptide expression also increased in embolized lungs, particularly in the muscular pulmonary arteries, compared with normal lungs. These findings suggest that ET-1 partially contributes to hemodynamic derangements of APE, and that ETA receptor antagonists might constitute a useful therapeutic tool for APE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:15:25