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Titolo:
A comparison of myocardial function after primary cardiac and primary asphyxial cardiac arrest
Autore:
Kamohara, T; Weil, MH; Tang, WC; Sun, SJ; Yamaguchi, H; Klouche, K; Bisera, J;
Indirizzi:
Inst Crit Care Med, Palm Springs, CA 92262 USA Inst Crit Care Med Palm Springs CA USA 92262 , Palm Springs, CA 92262 USA Univ So Calif, Keck Sch Med, Los Angeles, CA USA Univ So Calif Los Angeles CA USA alif, Keck Sch Med, Los Angeles, CA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 7, volume: 164, anno: 2001,
pagine: 1221 - 1224
SICI:
1073-449X(20011001)164:7<1221:ACOMFA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE EPINEPHRINE; CARDIOPULMONARY RESUSCITATION; VENTRICULAR-FIBRILLATION; DYSFUNCTION; DEFIBRILLATION; INCREASES; SEVERITY; MODEL; RATS;
Keywords:
cardiac arrest; ventricular fibrillations; asphyxia; myocardial function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Weil, MH Inst Crit Care Med, 1695 N Sunrise Way,Bldg 3, Palm Springs, CA 92262 USA Inst Crit Care Med 1695 N Sunrise Way,Bldg 3 Palm Springs CA USA 92262
Citazione:
T. Kamohara et al., "A comparison of myocardial function after primary cardiac and primary asphyxial cardiac arrest", AM J R CRIT, 164(7), 2001, pp. 1221-1224

Abstract

Although myocardial dysfunction after resuscitation from ventricular fibrillation (VF) has been extensively investigated, less is known of the function of the myocardium after asphyxial cardiac arrest. The present experimental study was designed to compare postresuscitation left ventricular (LV) function after cardiac arrest caused by asphyxia with that of cardiac arrest induced by dysrhythmia. Four groups of Sprague-Dawley rats, which included eight animals in each group, were investigated. In the first two groups, cardiac arrest followed asphyxia produced by neuromuscular blockade with and without airway obstruction. In a third group, cardiac arrest was induced byelectrical fibrillation of the ventricle. The fourth group represented animals in which the duration of asphyxial cardiac arrest was maintained for atime interval corresponding to that of the VF group. The fourth group received approximately the same number of electrical shocks as the third (VF) group. All animals were successfully resuscitated with precordial compression and mechanical ventilation. Postresuscitation measurements, including cardiac output, LV end-diastolic pressure (LVEDP), rate of pressure rise at LVpressure of 40 mm Hg (LV dP/dt(40)), and negative LV dP/dt, demonstrated decreased myocardial function in each group. No differences in cardiac function were observed between the animals with primary respiratory arrest whether or not the airway was obstructed. However, disproportionate and consistently greater impairment in myocardial function followed primary cardiac arrest due to VF when compared with equal duration of asphyxial cardiac arrest. We conclude that in this healthy animal model, asphyxial cardiac arrest resulted in significantly lesser impairment of postresuscitation myocardial function when compared with cardiac arrest caused by VF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:26:41