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Titolo:
Influence of preservation solution on early graft failure in clinical lungtransplantation
Autore:
Thabut, G; Vinatier, I; Brugiere, O; Leseche, G; Loirat, P; Bisson, A; Marty, J; Fournier, M; Mal, H;
Indirizzi:
Hop Beaujon, Serv Pneumol & Reanimat Resp, Clichy, France Hop Beaujon Clichy France Serv Pneumol & Reanimat Resp, Clichy, France Hop Beaujon, Serv Chirurg Thorac & Vasc, Clichy, France Hop Beaujon Clichy France n, Serv Chirurg Thorac & Vasc, Clichy, France Hop Beaujon, Serv Anesthesie & Reanimat, Clichy, France Hop Beaujon Clichy France n, Serv Anesthesie & Reanimat, Clichy, France Hop Foch, Grp Transplantat Pulm, Suresnes, France Hop Foch Suresnes France Foch, Grp Transplantat Pulm, Suresnes, France Univ Paris 07, INSERM, U408, Paris, France Univ Paris 07 Paris FranceUniv Paris 07, INSERM, U408, Paris, France
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 7, volume: 164, anno: 2001,
pagine: 1204 - 1208
SICI:
1073-449X(20011001)164:7<1204:IOPSOE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-POTASSIUM-DEXTRAN; UNIVERSITY-OF-WISCONSIN; PULMONARY REIMPLANTATION RESPONSE; ISCHEMIA-REPERFUSION INJURY; EURO-COLLINS SOLUTION; INTRACELLULAR SOLUTIONS; DONOR; TIME; PERMEABILITY; PROCUREMENT;
Keywords:
lung transplantation; organ preservation solutions; prognosis; reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mal, H Hop Beaujon, Serv Pneumol & Reanimat, 100 Ave Gen Leclerc, F-92110 Clichy,France Hop Beaujon 100 Ave Gen Leclerc Clichy France F-92110 lichy,France
Citazione:
G. Thabut et al., "Influence of preservation solution on early graft failure in clinical lungtransplantation", AM J R CRIT, 164(7), 2001, pp. 1204-1208

Abstract

The aim of this study was to assess the influence of preservation solutiontype and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris between 1988 and 1999, the preservation technique applied to the donor lung was single-flush perfusion of the pulmonary artery with one of several solutions of intracellular (Euro-Collins, n = 61; University of Wisconsin, n = 24) or extracellular composition (Cambridge, n = 64, Celsior, n = 21). The early postoperative outcome of these patients was reviewed. Reimplantation edema occurred in 48% of all patients, and the overall1-mo survival rate was 84%. No significant difference in the incidence of edema, duration of mechanical ventilation, and 1-mo survival rate was observed between the four groups or between intra- and extracellular groups, After adjustment for graft ischemic time by means of multivariate analysis, the use of extracellular preservation fluid was associated with a lower incidence of reimplantation edema without effect on 1-mo mortality. Graft ischemic time was associated with both edema occurrence and 1-mo survival rate (p= 0.02 and p = 0.01, respectively). We conclude that extracellular-type solutions are associated with better lung preservation than intracellular-type solutions in clinical transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:34:21