Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polymyositis-dermatomyositis-associated interstitial lung disease
Autore:
Douglas, WW; Tazelaar, HD; Hartman, TE; Hartman, RP; Decker, PA; Schroeder, DR; Ryu, JH;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Pulm & Crit Care Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Anat Pathol, Rochester, MN 55905 USA Mayo Clin &Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Diagnost Radiol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 diol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 7, volume: 164, anno: 2001,
pagine: 1182 - 1185
SICI:
1073-449X(20011001)164:7<1182:PILD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; TERM FOLLOW-UP; PROGNOSTIC-SIGNIFICANCE; HISTOLOGIC PATTERN; CT; PREDNISONE; ALVEOLITIS; PNEUMONIA; CYCLOPHOSPHAMIDE; AZATHIOPRINE;
Keywords:
polymyositis-dermatomyositis; interstitial lung disease; survival; azathioprine; prednisone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ryu, JH Mayo Clin & Mayo Fdn, Div Pulm & Crit Care Med, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5905 USA
Citazione:
W.W. Douglas et al., "Polymyositis-dermatomyositis-associated interstitial lung disease", AM J R CRIT, 164(7), 2001, pp. 1182-1185

Abstract

We report findings in 70 patients with both diffuse interstitial lung disease and either polymyositis (PM) or dermatomyositis (DM). Initial presentations were most commonly either musculoskeletal (arthralgias, myalgias, and weakness) or pulmonary (cough, dyspnea, and fever) symptoms alone; in only 15 patients (21.4%) did both occur simultaneously. Pulmonary disease usually took the form of acute to subacute antibiotic-resistant community-acquired pneumonia. Chest radiographs and computed tomography most commonly demonstrated bilateral irregular linear opacities involving the lung bases; occasionally consolidation was present. Jo-1 antibody was present in 19 (38%) of50 patients tested. Synchronous associated malignancy was present in 4 of 70 patients (5.7%). Surgical lung biopsies disclosed nonspecific interstitial pneumonia (NSIP) in 18 of 22 patients (81.8%), organizing diffuse alveolar damage (DAD) in 2, bronchiolitis obliterans organizing pneumonia (BOOP) in 1, and usual interstitial pneumonia (UIP) in 1. Treatment usually included prednisone in 40-60 mg/d dosages for initial control, followed by lower dose prednisone plus an immunosuppressive agent such as azathioprine or methotrexate for disease suppression. Survival was significantly better than that observed for historical control subjects with idiopathic UIP, and was more consistent with survival previously reported in idiopathic NSIP. There was no difference in survival between Jo-1 positive and Jo-1 negative groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:44:44