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Titolo:
Suppression of natural killer cell function and production of soluble ICAM-1: Endometrial stroma versus melanoma
Autore:
Vigano, P; Somigliana, E; Di Blasio, AM; Cozzolino, S; Candiani, M; Vignali, M;
Indirizzi:
Ist Auxol Italiano, Ist Sci Ctr, Milan, Italy Ist Auxol Italiano Milan Italy uxol Italiano, Ist Sci Ctr, Milan, Italy Univ Milan, Dept Obstet & Gynecol 2, Clin L Mangiagalli, Milan, Italy UnivMilan Milan Italy et & Gynecol 2, Clin L Mangiagalli, Milan, Italy
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 46, anno: 2001,
pagine: 342 - 348
SICI:
1046-7408(200111)46:5<342:SONKCF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; DIFFERENTIAL EXPRESSION; MURINE MODEL; SERUM LEVELS; RELEASE; CYTOTOXICITY; CULTURE; LYSIS; LINES;
Keywords:
endometrium; immune system; melanoma; NK cells; soluble intercellular adhesion molecule-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Vigano, P Ist Auxol Italiano, Ist Sci Ctr, Via Commenda 12, Milan, Italy Ist Auxol Italiano Via Commenda 12 Milan Italy 2, Milan, Italy
Citazione:
P. Vigano et al., "Suppression of natural killer cell function and production of soluble ICAM-1: Endometrial stroma versus melanoma", AM J REPROD, 46(5), 2001, pp. 342-348

Abstract

PROBLEM: It has been suggested that specific mechanisms commonly used by different cellular systems to evade immunologic recognition are involved in the development of endometriosis. To gain insight into this aspect, we looked at the relationship between two of these mechanisms in endometrial stroma and the melanoma system for which the ability to create an environment ofimmune privilege has been well established. METHOD OF STUDY: Media conditioned by endometrial stromal cultures and malignant melanoma A375 were examined to test their effects on peripheral blood mononuclear cell-mediated cytotoxicity directed against K562 target. Moreover, these media were tested for the concentration of the soluble form of intercellular adhesion molecule-1 (sICAM-1), which has been suggested as a marker for spreading potential. RESULTS: Media conditioned by endometrial stromal cultures exerted a significant suppressive effect on cell cytotoxicity when compared with those derived from malignant melanoma Moreover, the constitutive release of sICAM-1 was significantly higher in supernatants from endometrial stromal than in melanoma cells. CONCLUSIONS: These results indicate that two specific properties suggestedto be involved in the ability of tumor cells to evade the immune system are more pronounced in the endometrium than in a malignant melanoma. Since the properties evaluated have been previously demonstrated to be even more notable in endometrial samples derived from endometriosis patients. a role ofthese mechanisms in the development of the disease may be hypothesized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:22:52