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Titolo:
Different antiphospholipid antibody specificities are found in associationwith early repeated pregnancy loss versus recurrent IVF-failure patients
Autore:
Matsubayashi, H; Sugi, T; Arai, T; Kondo, A; Suzuki, T; Izumi, S; McIntyre, JA; Makino, T;
Indirizzi:
Tokai Univ, Sch Med, Dept Obstet & Gynecol, Ctr Growth & Reproduct Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Reproduct Med, Kanagawa 2591193, Japan St Francis Hosp, HLA Vasc Biol Lab, Indiana, PA USA St Francis Hosp Indiana PA USA Hosp, HLA Vasc Biol Lab, Indiana, PA USA
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 46, anno: 2001,
pagine: 323 - 329
SICI:
1046-7408(200111)46:5<323:DAASAF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; ANTICARDIOLIPIN ANTIBODIES; AUTOIMMUNE ANTIBODIES; NIMES OBSTETRICIANS; EMBRYO-TRANSFER; INVITRO FERTILIZATION; REPRODUCTIVE FAILURE; IMPLANTATION FAILURE; SPONTANEOUS-ABORTION; SEROPOSITIVE WOMEN;
Keywords:
cardiolipin; implantation failure; phosphatidylethanolamine; phosphatidylserine; recurrent pregnancy loss; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Matsubayashi, H Tokai Univ, Sch Med, Dept Obstet & Gynecol, Ctr Growth & Reproduct Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 anagawa 2591193, Japan
Citazione:
H. Matsubayashi et al., "Different antiphospholipid antibody specificities are found in associationwith early repeated pregnancy loss versus recurrent IVF-failure patients", AM J REPROD, 46(5), 2001, pp. 323-329

Abstract

PROBLEM: Patients having in vitro fertilization and embryo transfer (IVF-ET) failures show an increased incidence of antiphospholipid (aPL) antibodies; but controversy exists whether aPL can induce IVF-failure. This study was designed to compare aPL specificities between recurrent IVF-failure patients versus repeated early pregnancy loss (RPL) patients. METHOD OF STUDY: Anticardiolipin (aCL), lupus anticoagulant (LA), antiphosphatidylserine (aPS), antiphosphatidylethanolamine (aPE), and antinuclear antibodies (ANA) were measured in 74 recurrent IVF-ET failure patients and compared with 273 early RPL patients ( < 10 weeks). RESULTS: An increased incidence of IgG-aPE and ANA was observed for both groups in comparison with controls. Patients with recurrent IVF-ET failure showed a significantly higher prevalence of IgG-aPS (P = 0.02) and IgG-aCL (P = 0.02) when compared with early RPL patients or controls. CONCLUSIONS: IgG-aPS and IgG-aCL may be responsible for some IVF-failures. Additional studies are needed to clarify the pathogenic role of IgG-aPS and IgG-aCL on IVF-ET failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:39:52