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Titolo:
Increased natural killer-cell activity is associated with infertile women
Autore:
Matsubayashi, H; Hosaka, T; Sugiyama, Y; Suzuki, T; Arai, T; Kondo, A; Sugi, T; Izumi, S; Makino, T;
Indirizzi:
Tokai Univ, Sch Med, Dept Obstet & Gynecol, Ctr Growth & Reproduct Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Reproduct Med, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Psychiat & Biobehav Sci, Ctr Internal Med, Kanagawa, Japan Tokai Univ Kanagawa Japan obehav Sci, Ctr Internal Med, Kanagawa, Japan
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 46, anno: 2001,
pagine: 318 - 322
SICI:
1046-7408(200111)46:5<318:INKAIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; RECURRENT PREGNANCY LOSSES; STRESS; ENDOMETRIOSIS; EXPRESSION; ABORTION; IMMUNITY; FERTILE; CYTOTOXICITY; MISCARRIAGE;
Keywords:
depression; endometriosis; hyperprolactinemia; infertility; NK-cell activity; PTSD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matsubayashi, H Tokai Univ, Sch Med, Dept Obstet & Gynecol, Ctr Growth & Reproduct Med, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 anagawa 2591193, Japan
Citazione:
H. Matsubayashi et al., "Increased natural killer-cell activity is associated with infertile women", AM J REPROD, 46(5), 2001, pp. 318-322

Abstract

PROBLEM: An increase in natural killer (NK)-cell activity has been observed in women with unexplained recurrent miscarriages. Because of the many similarities between infertility and early pregnancy loss patients, we investigated whether infertile women had raised NK-cell activity. METHOD OF STUDY: We tested 94 infertile women who, in spite of treatment, were unable to conceive for 6 or more months. NK-cell activity was measuredby using a chromium-51 release cytotoxicity assay, with K562 human myeloidleukemia cells as targets. RESULTS: NK-cell activity of the infertile group (mean +/- SD; 40.2% +/- 14.7) was significantly higher than the control group (31.5% +/- 11.9, P < 0.0001). The increased NK-cell activity was not associated with age, infertile duration, depression scores, treated hyperprolactinemia, or treated endometriosis. CONCLUSIONS: In certain patients, elevated NK-cell activity may be considered an independent risk factor for infertility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:16:26