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Titolo:
Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins
Autore:
Todd, RD; Rasmussen, ER; Neuman, RJ; Reich, W; Hudziak, JJ; Bucholz, KK; Madden, PAF; Heath, A;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Univ Vermont, Dept Psychiat, Burlington, VT USA Univ Vermont Burlington VT USA ermont, Dept Psychiat, Burlington, VT USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 11, volume: 158, anno: 2001,
pagine: 1891 - 1898
SICI:
0002-953X(200111)158:11<1891:FAHOSO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT/HYPERACTIVITY DISORDER; LATENT CLASS; LINKAGE; ADHD; POLYMORPHISM; FAMILY; DRD4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Todd, RD Washington Univ, Sch Med, Dept Psychiat, Box 8134,660 S Euclid, St Louis, MO 63110 USA Washington Univ Box 8134,660 S Euclid St Louis MO USA63110 0 USA
Citazione:
R.D. Todd et al., "Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins", AM J PSYCHI, 158(11), 2001, pp. 1891-1898

Abstract

Objective: Attention deficit hyperactivity disorder (ADHD) is a highly heritable but clinically heterogeneous syndrome. The study examined the familiality and heritability of ADHD subtypes as defined by DSM-IV and by latent-class analysis in a population sample of adolescent female twins. Method: To determine which elements of ADHD cluster together, latent-classanalysis was applied to data obtained from parents on the 18 DSM-IV ADHD symptoms in 4,036 female twins age 13-23 years in a population sample identified from the registry of all births in Missouri for the years 1968-1996. Relative risk and odds ratios were used to assess within-subtype and between-subtype familiality and heritability of both DSM-IV and latent-class ADHD subtypes. Results: Latent-class analysis was most compatible with the existence of three mild and three severe classes of ADHD symptoms in the general population. The three severe classes showed moderate overlap with DSM-IV ADHD subtypes. The primarily inattentive and combined subtypes of DSM-IV ADHD co-clustered within families. The primarily hyperactive/impulsive DSM-IV subtype and the individual latent-class analysis subtypes did not co-cluster. Subtypes defined by both approaches were highly heritable. Conclusions: Unlike DSM-IV subtypes of ADHD, latent-class ADHD subtypes appear to be independently transmitted in families. These classes may be moreappropriate targets for molecular genetic studies of ADHD.

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Documento generato il 11/07/20 alle ore 03:52:48