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Titolo:
Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization
Autore:
Buetow, BS; Crosby, JR; Kaminski, WE; Ramachandran, RK; Lindahl, P; Martin, P; Betsholtz, C; Seifert, RA; Raines, EW; Bowen-Pope, DF;
Indirizzi:
Univ Washington, Dept Pathol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pathol, Seattle, WA 98195 USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 159, anno: 2001,
pagine: 1869 - 1876
SICI:
0002-9440(200111)159:5<1869:PGFBOH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; BLOOD-VESSEL FORMATION; ANGIOGENESIS IN-VITRO; ENDOTHELIAL-CELLS; PDGF-B; ANALYSIS REVEALS; BETA-RECEPTORS; MICE; PERICYTES; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Bowen-Pope, DF Univ Washington, Dept Pathol, Box 357470, Seattle, WA 98195USA Univ Washington Box 357470 Seattle WA USA 98195 A 98195 USA
Citazione:
B.S. Buetow et al., "Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization", AM J PATH, 159(5), 2001, pp. 1869-1876

Abstract

The hypothesis that wound repair is augmented by delivery of platelet-derived growth factor (PDGF) from platelets and macrophages is an attractive extrapolation from the known activities of PDGF in cell culture and in vivo. To test this hypothesis in mice, we prepared hematopoietic chimeras, in which the hematopoietic system of a normal adult mouse was replaced by the hematopoietic system of a PDGF B-chain -/- or +/+ donor. We initiated local granulation tissue formation either by implanting small surgical sponges to elicit a foreign body granulation tissue response, or by ligating the left common carotid to form an organized thrombus. We found that the absence of hematopoietic PDGF B-chain did not decrease the extent of granulation tissueor vascular lesion formation, and that the vascularization of both lesionsincreased by similar to 100%. We conclude that PDGF B-chain from cells of hematopoietic origin, including platelets and macrophages, is not importantfor granulation tissue formation, and that it reduces vascularization of granulation issue, probably through disabling of the short-range chemotacticgradients of PDGF that are important for recruiting pericytes/smooth muscle cells to the endothelium of new vessels.

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Documento generato il 02/12/20 alle ore 18:22:41