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Titolo:
Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model
Autore:
Zeitvogel, A; Baumann, R; Starzinski-Powitz, A;
Indirizzi:
Univ Frankfurt, Inst Anthropol & Humangenet Biol, D-60054 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60054 iol, D-60054 Frankfurt, Germany Burgerhosp Frankfurt Main, Frankfurt, Germany Burgerhosp Frankfurt Main Frankfurt Germany rt Main, Frankfurt, Germany
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 159, anno: 2001,
pagine: 1839 - 1852
SICI:
0002-9440(200111)159:5<1839:IOAINE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE-T-ANTIGEN; PERITONEAL-FLUID CONCENTRATIONS; TRANSCRIPTION FACTOR LEF-1; CELOMIC METAPLASIA THEORY; MOLECULE E-CADHERIN; IN-VITRO; AROMATASE CYTOCHROME-P450; CATENIN COMPLEXES; CARCINOMA-CELLS; BREAST-CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Starzinski-Powitz, A Univ Frankfurt, Inst Anthropol & Humangenet Biol, Siesmayerstr 70, D-60054Frankfurt, Germany Univ Frankfurt Siesmayerstr 70 Frankfurt Germany D-60054
Citazione:
A. Zeitvogel et al., "Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model", AM J PATH, 159(5), 2001, pp. 1839-1852

Abstract

Studies of molecular, cellular, and pathophysiological parameters in endometriosis are primarily hampered by a lack of in vitro model systems, such as endometriotic cell lines. To overcome this we successfully established cell lines from peritoneal endometriotic biopsies and characterized them at the molecular and cellular level. Two types of cells could he transformed: one exhibiting stromal. cell features (cytokeratin/E-cadherin-negative), theother epithelial-like (cytokeratin-positive/E-cadherin-negative, invasive in vitro). Using a Matrigel assay the epithelial-like cell lines proved as invasive as metastatic carcinoma cells, possibly through the influence of N-cadherin implicated as a path-finding cadherin allowing cellular invasion and migration in both normal and pathophysiological processes. Our results support the idea that endometriosis, although not neoplastic, shares features with malignant cells and that metastasis in endometriosis may include mechanisms proposed for micrometastasis in cancer. Thus our cell Lines will not only be useful tools for analyzing molecular and cellular events relating to endometriosis, but may also represent a paradigm for invasion and metastasis in general.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:16:58