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Titolo:
Active-control equivalence trials and antihypertensive agents
Autore:
McAlister, FA; Sackett, DL;
Indirizzi:
Univ Alberta, Div Gen Internal Med, Edmonton, AB T6G 2M7, Canada Univ Alberta Edmonton AB Canada T6G 2M7 Med, Edmonton, AB T6G 2M7, Canada Inst Hlth econ, Edmonton, AB, Canada Inst Hlth econ Edmonton AB CanadaInst Hlth econ, Edmonton, AB, Canada Trout Res & Educ Ctr, Irish Lake, ON, Canada Trout Res & Educ Ctr Irish Lake ON Canada uc Ctr, Irish Lake, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 7, volume: 111, anno: 2001,
pagine: 553 - 558
SICI:
0002-9343(200111)111:7<553:AETAAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIALS; PLACEBO-CONTROLLED TRIALS; CALCIUM-ANTAGONISTS; CARDIOVASCULAR MORBIDITY; BLOOD-PRESSURE; SWEDISH TRIAL; BETA-BLOCKERS; OLD PATIENTS; HYPERTENSION; MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: McAlister, FA Univ Alberta Hosp, 2E3-24 WMC,8440 112 St, Edmonton, AB T6G 2R7, Canada Univ Alberta Hosp 2E3-24 WMC,8440 112 St Edmonton AB Canada T6G2R7
Citazione:
F.A. McAlister e D.L. Sackett, "Active-control equivalence trials and antihypertensive agents", AM J MED, 111(7), 2001, pp. 553-558

Abstract

PURPOSE: To identify methodological features that affect the validity of conclusions drawn from active-control equivalence trials and to apply these criteria to recently published trials comparing antihypertensive agents from different classes. METHODS: Standard methodological criteria for randomized clinical trials and six additional methodological features that affect the validity of active-control equivalence trials were applied to four recently published large trials that compared different antihypertensive classes and that concluded that their results showed equivalence. RESULTS: All four of these trials fulfilled standard criteria for randomized trials. However, none fulfilled all of the six additional methodologicalcriteria that affect the validity of active-control equivalence trials, one fulfilled five criteria, two fulfilled two criteria, and one failed to fulfill any of the criteria. CONCLUSION: Standard methodological criteria for evaluating superiority trials are inadequate for the interpretation of active-control equivalence trials. The methodological criteria outlined in this article for judging the validity of active-control equivalence trials are not specific to antihypertensive trials and may be applied to trials that test a wide variety of interventions. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:03:23