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Titolo:
ANCA-associated vasculitis in Greek siblings with chronic exposure to silica
Autore:
Brener, Z; Cohen, L; Goldberg, SJ; Kaufman, AM;
Indirizzi:
Beth Israel Med Ctr, Dept Med, Div Nephrol & Hypertens, New York, NY 10003USA Beth Israel Med Ctr New York NY USA 10003 ypertens, New York, NY 10003USA Jewish Hosp, Dept Med, Cincinnati, OH USA Jewish Hosp Cincinnati OH USAJewish Hosp, Dept Med, Cincinnati, OH USA Jewish Hosp, Serv Nephrol, Cincinnati, OH USA Jewish Hosp Cincinnati OH USA ish Hosp, Serv Nephrol, Cincinnati, OH USA
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 5, volume: 38, anno: 2001,
pagine: NIL_26 - NIL_28
SICI:
0272-6386(200111)38:5<NIL_26:AVIGSW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEGENERS GRANULOMATOSIS; SYSTEMIC VASCULITIS; GLOMERULONEPHRITIS; ANTIGENS;
Keywords:
systemic vasculitis; antineutrophil cytoplasmic antibodies (ANCA); rapidly progressive glomerulonephritis; silica; human leukocyte antigens (HLA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Brener, Z 104-40 Queens Blvd,Apt 22J, Forest Hills, NY 11375 USA 104-40 Queens Blvd,Apt 22J Forest Hills NY USA 11375 11375 USA
Citazione:
Z. Brener et al., "ANCA-associated vasculitis in Greek siblings with chronic exposure to silica", AM J KIDNEY, 38(5), 2001, pp. NIL_26-NIL_28

Abstract

We present the case of two siblings with similar environmental exposure tosilica. Both of them developed perinuclear antineutrophil cytoplasmic antibody (p-ANCA)-associated vasculitis with pulmonary-renal syndrome. p-ANCAs were present with anti myeloperoxidase specificity on capture enzyme-linkedimmunosorbent assay. Treatment with corticosteroids and cyclophosphamide resulted in resolution of the clinical picture. Chronic exposure to silica is the leading environmental factor associated with ANCA-positive vasculitis. Several clusters of systemic vasculitis have been described. Positive andnegative human leukocyte antigens (HLA) have been reported In systemic vasculitis. Affected brothers in our case shared one parental HLA haplotype. To the best of our knowledge, this is the first report of a family cluster of silica-induced, ANCA-associated systemic vasculitis with members sharing some of their HLA antigens, (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:46:27