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Titolo:
Iron deposition in renal biopsy specimens from patients with kidney diseases
Autore:
Wang, HG; Nishiya, K; Ito, H; Hosokawa, T; Hashimoto, K; Moriki, T;
Indirizzi:
Kochi Med Sch, Dept Internal Med 2, Nankoku, Kochi 7838505, Japan Kochi Med Sch Nankoku Kochi Japan 7838505 , Nankoku, Kochi 7838505, Japan Kochi Med Sch, Dept Clin Lab Med, Nankoku, Kochi 7838505, Japan Kochi Med Sch Nankoku Kochi Japan 7838505 , Nankoku, Kochi 7838505, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1038 - 1044
SICI:
0272-6386(200111)38:5<1038:IDIRBS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFERRIN;
Keywords:
iron deposition; renal biopsy specimens; benign nephrosclerosis; immunoglobulin A (IgA); nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nishiya, K Kochi Med Sch, Dept Internal Med 2, Okoh Cho, Nankoku, Kochi 7838505, Japan Kochi Med Sch Okoh Cho Nankoku Kochi Japan 7838505 38505, Japan
Citazione:
H.G. Wang et al., "Iron deposition in renal biopsy specimens from patients with kidney diseases", AM J KIDNEY, 38(5), 2001, pp. 1038-1044

Abstract

This study was performed to investigate the correlation between clinical parameters and! grading of iron deposition in renal biopsy specimens from 102 patients with various kidney diseases. Iron deposition in renal tissues was detected by Berlin blue staining. The extent of iron staining was semiquantitatively graded as negative (Fe-), grade 0, or positive (Fe+), including faint, grade 1; moderate, grade 2; or severe, grade 3, by light microscopy. Thirty-four of 102 patients (33%) showed positive iron staining. Fe+ patients had various renal diseases, mainly consisting of 12 patients with immunoglobulin A nephropathy and 5 patients with benign nephrosclerosis. Mean arterial pressure (MAP), serum creatinine (sCr) levels, incidence of hematuria, and urinary N-acety beta -D-glucosaminidase (u-NAG) levels in Fe+ patients were significantly greater than those in Fe+ patients, and u-NAG levels correlated positively with the extent of iron deposition. Study patients were tentatively divided into two groups according to the extent of iron deposition:. group A, patients with grades 2 and 3 staining, and group B, patients with grades 0 and I staining. In group A, MAP, sCr level, urinary protein excretion, and the incidence of hematuria were significantly greater than in group B. Our results suggest that the amount of iron deposition in renal tissue may contribute to the progression of chronic renal disease and may be an early and sensitive indicator of renal damage in certain renal diseases. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:17:46