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Titolo:
Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy
Autore:
Uesugi, N; Sakata, N; Horiuchi, S; Nagai, R; Takeya, M; Meng, J; Saito, T; Takebayashi, S;
Indirizzi:
Fukuoka Univ, Sch Med, Dept Pathol 2, Jonan Ku, Fukuoka 8140133, Japan Fukuoka Univ Fukuoka Japan 8140133 l 2, Jonan Ku, Fukuoka 8140133, Japan Fukuoka Univ, Sch Med, Dept Internal Med, Jonan Ku, Fukuoka 8140133, JapanFukuoka Univ Fukuoka Japan 8140133 Med, Jonan Ku, Fukuoka 8140133, Japan Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 Med, Dept Biochem, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Pathol 2, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 Med, Dept Pathol 2, Kumamoto 860, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 5, volume: 38, anno: 2001,
pagine: 1016 - 1025
SICI:
0272-6386(200111)38:5<1016:GMALPP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; GLOMERULAR-LESIONS; MODIFIED PROTEINS; GROWTH-FACTOR; RECEPTOR; PATHOGENESIS; DEGRADATION; BINDING; STRESS;
Keywords:
glycoxidation product; carboxymethyllysine (CML); lipid peroxidation product; macrophage; foamy macrophage; diabetic glomerulosclerosis (DGS); macrophage scavenger receptor (MSR) class A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Takebayashi, S Fukuoka Univ, Sch Med, Dept Pathol 2, Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140133, Japan Fukuoka Univ 7-45-1 Nanakuma Fukuoka Japan 8140133 , Japan
Citazione:
N. Uesugi et al., "Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy", AM J KIDNEY, 38(5), 2001, pp. 1016-1025

Abstract

The aim of this study is to Investigate the role of glomerular macrophagesactivated by glycoxidation and lipid peroxidation products in the progression of glomerular lesions In diabetic nephropathy. Renal biopsy samples from 43 patients with diabetes (age, 54 +/- 14 years) and 10 control cases were immunohistochemically examined for the expression of carboxymethyllysine (CML), a representative glycoxidative product; oxidized phosphatidylcholine(OX-PC), a representative lipid peroxidation product; leukocyte common antigen (LCA); CD68; and macrophage scavenger receptor (MSR) class A. The severity of the diffuse lesions in each glomerulus was histologically graded from 0 to IV. When grade II and III lesions had Kimmelstiel-Wilson (KW) nodules, they were placed in a new category called grade III with KW nodules. The number of cells positive for CML, Ox-PC, LCA, CD68, and MSR was compared in different grades. The number of macrophages per glomerulus increased with the glomerular lesion grade and was highest in grade III with KW nodules. Conversely, the number of lymphocytes did not parallel the grade of glomerular lesions. Almost 50% of macrophages contained CML, and more than 40% ofthose were observed in exudative lesions, tuft. adhesions, and at the periphery of KW nodules. Ox-PC accumulated in 50% of CML-positive macrophages, which coexpress MSR. Macrophages positive for CML and Ox-PC increased with the grade. Glomerular macrophages may be activated by glycoxidative and lipid peroxidation products through MSR and may have a role In the developmentof human diabetic glomerulosclerosis. (C) 2001 by the National Kidney Foundation, Inc.

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Documento generato il 29/09/20 alle ore 23:26:03