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Titolo:
Increased prevalence of combined MTR and MTHFR genotypes among individualswith severely elevated total homocysteine plasma levels
Autore:
Feix, A; Fritsche-Polanz, R; Kletzmayr, J; Vychytil, A; Horl, WH; Sunder-Plassmann, G; Fodinger, M;
Indirizzi:
Univ Vienna, Dept Med 3, Div Nephrol & Dialysis, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 rol & Dialysis, A-1010 Vienna, Austria Univ Vienna, Dept Lab Med, Div Endocrinol & Metab, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 crinol & Metab, A-1010 Vienna, Austria
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 5, volume: 38, anno: 2001,
pagine: 956 - 964
SICI:
0272-6386(200111)38:5<956:IPOCMA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; HUMAN METHIONINE SYNTHASE; NEURAL-TUBE DEFECTS; STAGE RENAL-DISEASE; DOSE FOLIC-ACID; HEMODIALYSIS-PATIENTS; METHYLMALONIC ACID; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; GRAFT RECIPIENTS; VASCULAR-DISEASE;
Keywords:
methionine synthase (MTR); 5,10-methylenetetrahydrofolate reductase (MTHFR); polymorphism; total homocysteine (tHcy); folate; vitamin B-12; hemodialysis (HD); peritonea[ dialysis (PD); kidney transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Feix, A Univ Vienna, Innere Med Klin 3, Klin Abt Nephrol & Dialyse, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20Vienna Austria A-1090 Austria
Citazione:
A. Feix et al., "Increased prevalence of combined MTR and MTHFR genotypes among individualswith severely elevated total homocysteine plasma levels", AM J KIDNEY, 38(5), 2001, pp. 956-964

Abstract

The prevalence of the methionine synthase (MTR) 2756A -->G polymorphism among individuals with severely elevated total homocysteine (tHcy) plasma levels is unknown. Therefore, 1,716 subjects, including 415 hemodialysis patients, 179 peritoneal dialysis patients, 733 kidney graft recipients, and 389healthy subjects, were investigated. The distribution of MTR 2756A -->G, as well as 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C -->T/1298A -->C, genotypes among study participants with extremely high tHcy plasma levels (>90th percentile) was compared with the genotype distribution of subjects with very low tHcy plasma levels (<10th percentile). The prevalence ofMTR 2756AG and GG genotypes alone did not differ between individuals with extremely high or extremely low tHcy levels (P = 0.7402; odds ratio [OR], 1.076; 95% confidence interval [CI], 0.697 to 1.662). Conversely, combined MTR and MTHFR genotypes, (MTR 2756AG and 2756GG and MTHFR 677TT/1298AA and 677CT/1298AC) were found more often in the highest (n = 34) compared with the lowest plasma tHcy decile (n = 19; P = 0.0252; OR, 1.983; 95% Cl, 1.079 to 3.643). The number of patients with the wild-type MTR and MTHFR genotype was three times greater in the lowest compared with the highest decile (17 versus 6 patients, respectively; P = 0.0155; OR, 0.330; 95% Cl, 0.126 to 0.861). In summary, our study shows that the 2756A<right arrow>G transition of MTR in combination with MTHFR 677TT/1298AA and 677CT/1298AC can be associated with extremely high tHcy plasma levels. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:01:03