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Titolo:
Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: The HERITAGE Family Study
Autore:
An, P; Rice, T; Gagnon, J; Borecki, IB; Rankinen, T; Gu, C; Leon, AS; Skinner, JS; Wilmore, JH; Bouchard, C; Rao, DC;
Indirizzi:
Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA CHUL, Res Ctr, Mol Endocrinol Lab, St Foy, PQ, Canada CHUL St Foy PQ Canada L, Res Ctr, Mol Endocrinol Lab, St Foy, PQ, Canada Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USALouisiana State Univ Baton Rouge LA USA 70808 , Baton Rouge, LA 70808 USA Univ Minnesota, Sch Kinesiol & Leisure Studies, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA & Leisure Studies, Minneapolis, MN USA Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 Kinesiol, Bloomington, IN 47405 USA Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA Texas A&M Univ College Stn TX USA t Hlth & Kinesiol, College Stn, TX USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF HUMAN BIOLOGY
fascicolo: 6, volume: 13, anno: 2001,
pagine: 832 - 837
SICI:
1042-0533(200111/12)13:6<832:PDITPO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE WOMEN; PROGRAM; TWINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: An, P Washington Univ, Sch Med, Div Biostat, Campus Box 8067,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Campus Box 8067,660 S Euclid Ave St Louis MO USA 63110
Citazione:
P. An et al., "Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: The HERITAGE Family Study", AM J HUM B, 13(6), 2001, pp. 832-837

Abstract

Familial influences were investigated for baseline sex hormone-binding globulin (SHBG) and its response (post-training minus baseline) to a 20-week endurance exercise training program. One hundred, eighty-four participants from 85 Black families in the HERITAGE Family Study (HERITAGE) were analyzedusing a familial correlation model. Baseline SHBG values and the training response were adjusted for the effects of age, baseline BMI, testosterone, estradiol, and fasting insulin levels (plus baseline SHBG values for the training response) within four sex-by-generation groups prior to genetic analysis. Baseline SHBG levels were influenced by appreciable familial effects (maximum heritability h(2) = 54%) with neither spouse resemblance nor sex and generation differences in the correlations. This estimate is only slightly, but not significantly, smaller than the heritability of 64% reported previously in 428 participants from 99 White families in HERITAGE. In contrast to the modest familial effects for the training response in White participants in HERITAGE (h(2) = 25%), there were no evidence of familial resemblance in Blacks in the current study. Furthermore, there was heterogeneity for both baseline SHBG and the training response between Blacks and Whites inthe pattern of familial aggregation. In conclusion, baseline SHBG levels are influenced by significant familial effects in both Blacks and Whites, independent of the effects of age, sex, and baseline values of BMI. testosterone, estradiol, and fasting insulin levels. Whereas modest familial effectswere detected for the training response in Whites, the lack of similar effects in Blacks may be due to the smaller sample size. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 09:28:59