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Titolo:
Prolonged general anesthesia in MR studies of rats
Autore:
Wood, AKW; Klide, AM; Pickup, S; Kundel, HL;
Indirizzi:
Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 n Studies, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
ACADEMIC RADIOLOGY
fascicolo: 11, volume: 8, anno: 2001,
pagine: 1136 - 1140
SICI:
1076-6332(200111)8:11<1136:PGAIMS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED RATS; ISOFLURANE; KETAMINE/MEDETOMIDINE; BUPRENORPHINE; MODEL; BLUE;
Keywords:
rat; anesthesia; isoflurane; magnetic resonance (MR) imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wood, AKW Univ Penn, Sch Vet Med, Dept Clin Studies, 3850 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3850 Spruce St Philadelphia PA USA 19104 PA 19104 USA
Citazione:
A.K.W. Wood et al., "Prolonged general anesthesia in MR studies of rats", ACAD RADIOL, 8(11), 2001, pp. 1136-1140

Abstract

Rationale and Objectives. Magnetic resonance (MR) imaging of laboratory animals may require general anesthesia to minimize body movements over many hours. The anesthetization technique should allow physiologic parameters to remain as close to normal as possible, permit fast recovery, allow safe, repeated use, and avoid attachment of ferrous metal components to the animal. The purpose of this study was to evaluate an anesthetization technique that was developed to meet each of these qualifications. Materials and Methods. In 15 rats (280-483-g body weight), general anesthesia was induced (with intramuscular ketamine hydrochloride, xylazine hydrochloride, acepromazine maleate, and atropine), a tail vein catheter was inserted, and preimaging surgical procedures were performed. A face mask was applied, the animal was positioned in a dorsal recumbent position on an acrylic board, and an isothermal heating pad was placed on the ventral aspect ofthe abdominal wall. The rat, on the board, was then inserted into a troughthat contained a custom-built, linearly polarized birdcage head coil and placed in the bore of a 4.7-T horizontal-bore magnet. The face mask was connected to a non-rebreathing gaseous anesthetic system, and anesthesia was maintained with 1.5-2.0 L/min oxygen and 0.25%-1.50% isoflurane. Oxygen saturation, heart rate, and rectal temperature were continuously monitored. Results. The duration of intramuscular anesthesia was 110 minutes +/- 12, and the duration of gaseous anesthesia was 106 minutes +/- 43. The monitoring equipment permitted display of vital signs. Conclusion. The method appeared safe, was easy to perform, maintained a stable physiologic state for the parameters monitored, and could be used for repeated anesthesia in the same animal.

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Documento generato il 06/04/20 alle ore 05:44:31