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Titolo:
Decoding the language of var genes and Plasmodium falciparum sequestration
Autore:
Smith, JD; Gamain, B; Baruch, DI; Kyes, S;
Indirizzi:
Colorado State Univ, Dept Pathol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 hol, Ft Collins, CO 80523 USA NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA John Radcliffe Hosp, Mol Parasitol Grp, Inst Mol Med, Nuffield Dept Med, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Med, Oxford OX3 9DU, England
Titolo Testata:
TRENDS IN PARASITOLOGY
fascicolo: 11, volume: 17, anno: 2001,
pagine: 538 - 545
SICI:
1471-4922(200111)17:11<538:DTLOVG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE-MEMBRANE PROTEIN-1; CHONDROITIN SULFATE-A; INTERCELLULAR-ADHESION MOLECULE-1; HISTIDINE-RICH PROTEIN; INFECTED ERYTHROCYTES; BINDING DOMAINS; ANTIGENIC VARIATION; GEOGRAPHIC REGIONS; P-FALCIPARUM; RED-CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, JD Colorado State Univ, Dept Pathol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 llins, CO 80523 USA
Citazione:
J.D. Smith et al., "Decoding the language of var genes and Plasmodium falciparum sequestration", TRENDS PARA, 17(11), 2001, pp. 538-545

Abstract

Sequestration and rosetting are key determinants of Plasmodium falciparum pathogenesis. They are mediated by a large family of variant proteins called P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 proteins are multispecific binding receptors that are transported to parasite-induced,'knob-like' binding structures at the erythrocyte surface. To evade immunity and extend infections, parasites clonally vary their expressed PfEMP1. Thus, PfEMP1 are functionally selected for binding while immune selection acts to diversity the family. Here,we describe a new way to analyse PfEMP1 sequence that provides insight into domain function and protein architecture with potential implications for malaria disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:16:03