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Titolo:
Treatment of intestinal graft-versus-host disease using betamethasone enemas
Autore:
Wada, H; Mori, A; Okada, M; Takatsuka, H; Tamura, A; Seto, Y; Iwata, N; Fujimori, Y; Okamoto, T; Takemoto, Y; Kakishita, E;
Indirizzi:
Hyogo Med Univ, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
TRANSPLANTATION
fascicolo: 8, volume: 72, anno: 2001,
pagine: 1451 - 1453
SICI:
0041-1337(20011027)72:8<1451:TOIGDU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; CONTROLLED TRIAL; MICE; BECLOMETHASONE; THERAPY; GVHD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, H Hyogo Med Univ, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501 an
Citazione:
H. Wada et al., "Treatment of intestinal graft-versus-host disease using betamethasone enemas", TRANSPLANT, 72(8), 2001, pp. 1451-1453

Abstract

Intestinal graft-versus-host disease (GVHD) can readily easily induce generalized metabolic disturbance that influences morbidity and mortality afterallogeneic bone marrow transplantation. Although adding a new drug or increasing the doses of immunosuppressive agents will probably be effective forcontrolling intestinal GVHD, the systemic side effects of such therapy cannot be ignored. In this study, we used betamethasone retention enemas as a local treatment for eight patients with refractory and/or severe intestinalGVHD. Six of the eight patients showed improvement of diarrhea and/or abdominal pain, with a reduction in the stage of GVHD. When treatment with betamethasone enemas was continued for 10 to 27 days in the 6 responding patients, no severe toxicity was observed. One patient failed to respond to treatment and another could not tolerate the enemas. Despite some uncertainty regarding the indications and duration of treatment, betamethasone enemas seem to be a potential alternative method for the management of intestinal GVHD. Despite recent progress in the management of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT), it is still one of the most important complications. Intestinal GVHD presents with watery orbloody diarrhea and/or abdominal pain, which is occasionally complicated by ileus (1). Appropriate treatment is needed, because intestinal GVHD can readily cause complications that influence the outcome of BMT. The recommended treatment for intestinal GVHD is generally systemic administration of immunosuppressive agents such as glucocorticoids or antithymocyte globulin (2). Although these treatments are generally effective, symptoms may persist despite powerful and long-term immunosuppression in some patients. In such cases, various side effects of the drugs may occur, including fatal opportunistic infections, especially those caused by cytomegalovirus. In our study, we treated eight patients who had severe and refractory intestinal GVHD with betamethasone enemas as a local therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:39:55