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Titolo:
Thrombolytic therapy - State of the art
Autore:
Sinnaeve, P; Van de Werf, F;
Indirizzi:
Katholieke Univ Leuven, Dept Cardiol, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium , Dept Cardiol, Louvain, Belgium
Titolo Testata:
THROMBOSIS RESEARCH
, volume: 103, anno: 2001, supplemento:, 1
pagine: S71 - S79
SICI:
0049-3848(20010930)103:<S71:TT-SOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; TISSUE-PLASMINOGEN-ACTIVATOR; FRONT-LOADED ALTEPLASE; DOUBLE-BOLUS RETEPLASE; RECOMBINANT STAPHYLOKINASE; CORONARY THROMBOLYSIS; FIBRIN SPECIFICITY; DOUBLE-BLIND; TRIAL; PATENCY;
Keywords:
acute myocardial infarction; thrombolytic therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Van de Werf, F Univ Hosp Gasthuisberg, Dept Cardiol, Herestr 49, B-3000 Louvain, Belgium Univ Hosp Gasthuisberg Herestr 49 Louvain Belgium B-3000 m
Citazione:
P. Sinnaeve e F. Van de Werf, "Thrombolytic therapy - State of the art", THROMB RES, 103, 2001, pp. S71-S79

Abstract

Thrombolytic agents have become the corner stone in the treatment of acutemyocardial infarction. However, the current agents are far from perfect. New thrombolytic drugs have been designed to overcome these shortcomings. Development of these agents has focused not only on increasing plasma half-life and thus allowing single-bolus administration, but also on improving fibril specificity and resistance to plasminogen activator inhibitor. The safety and efficacy of several of these promising thrombolytic drugs have been evaluated in large-scale trials, which are discussed in the present review. Parallel to these advances, alternatives to standard thrombolytic regimenshave been developed. New trials evaluating the combination of reduced dosefibrinolytics with different regimens of antithrombotic agents will optimize future reperfusion strategies. (C) 2001 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:24:57