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Titolo:
Ketamine alters the availability of striatal dopamine transporter as measured by [C-11]beta-CFT and [C-11]beta-CIT-FE in the monkey brain
Autore:
Tsukada, H; Nishiyama, S; Kakiuchi, T; Ohba, H; Sato, K; Harada, N;
Indirizzi:
Hamamatsu Photon KK, Cent Res Labs, Shizuoka 4348601, Japan Hamamatsu Photon KK Shizuoka Japan 4348601 Labs, Shizuoka 4348601, Japan
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 273 - 280
SICI:
0887-4476(200112)42:4<273:KATAOS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; C-11 BETA-CIT; IN-VIVO; ISOFLURANE ANESTHESIA; RACLOPRIDE BINDING; RHESUS-MONKEY; RECEPTOR; PET; RAT; MICRODIALYSIS;
Keywords:
ketamine; dopamine transporter; [C-11]beta-CFT; [C-11]beta-CIT-FE; positron emission tomography; monkey brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, H Hamamatsu Photon KK, Cent Res Labs, 5000 Hirakuchi, Shizuoka 4348601, Japan Hamamatsu Photon KK 5000 Hirakuchi Shizuoka Japan 4348601 apan
Citazione:
H. Tsukada et al., "Ketamine alters the availability of striatal dopamine transporter as measured by [C-11]beta-CFT and [C-11]beta-CIT-FE in the monkey brain", SYNAPSE, 42(4), 2001, pp. 273-280

Abstract

The effects of ketamine anesthesia on the binding of [C-11]-labeled cocaine analogs, [C-11]beta -CFT (2 beta -carbomethoxy-3 beta-(4-fluorophenyl)tropane) and [C-11]beta -CIT-FE (N-(2-fluoroethyl)-2 beta -carbomethoxy-3 beta-(4-iodophenyl)tropane), to the striatal dopamine transporter (DAT) were evaluated in the monkey brain using positron emission tomography (PET). We sequentially measured the kinetics of these labeled compounds in the brains of five young-adult male rhesus monkeys (Macaca mulatta) in the conscious state, followed by those under ketamine anesthesia with continuous infusion (3 and 10 mg/kg/h). After intravenous injection, [C-11]beta -CFT and [C-11]beta -CIT-FE were predominantly accumulated in the striatum in both conscious and ketamine-anesthetized states. In the conscious state, the striatal uptake of [C-11]beta -CFT and [C-11]beta -CIT-FE continuously increased with time up to 91 min after injection. Continuous infusion of ketamine-induced higher levels of uptake of [C-11]beta -CFT and [C-11]beta -CIT-FE into the brain in a dose-dependent manner as compared with conscious state, and kinetic analysis with metabolite-corrected arterial input function indicated that the binding potentials (BP = k(3)/k(4)) of both compounds were elevated by ketamine. Not only [C-11]beta -CIT-FE but also [C-11]beta -CFT reached the equilibrium state of specific binding in the striatum within 40-50 min after injection. The present results demonstrated that ketamine significantly alters the DAT availability as measured with [C-11]beta -CFT and [C-11]beta -CIT-FE in the brain. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:48:10