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Titolo:
Changes in neuronal activation with increasing attention demand in healthyvolunteers: An fMRI study
Autore:
Adler, CM; Sax, KW; Holland, SK; Schmithorst, V; Rosenberg, L; Strakowski, SM;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Psychiat, Bipolar & Psychot Disorders Res Program, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Program, Cincinnati, OH 45267 USA Univ Cincinnati, Childrens Hosp, Ctr Med, Imaging Res Ctr, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA d, Imaging Res Ctr, Cincinnati, OH USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 266 - 272
SICI:
0887-4476(200112)42:4<266:CINAWI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CONTINUOUS PERFORMANCE-TEST; VERSION CPT-IP; SUSTAINED ATTENTION; RETROSPECTIVE ESTIMATION; SELECTIVE ATTENTION; PREFRONTAL CORTEX; WORKING-MEMORY; BLOOD-FLOW; SCHIZOPHRENIA;
Keywords:
neuroimaging; degraded stimulus; identical pairs; human; CPT; cognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, CM Univ Cincinnati, Coll Med, Dept Psychiat, Bipolar & Psychot Disorders Res Program, 231 Bethesda Ave, Cincinnati, OH 45267 USA Univ Cincinnati 231 Bethesda Ave Cincinnati OH USA 45267 267 USA
Citazione:
C.M. Adler et al., "Changes in neuronal activation with increasing attention demand in healthyvolunteers: An fMRI study", SYNAPSE, 42(4), 2001, pp. 266-272

Abstract

Several lines of evidence suggest that structures involved in mediating attention differentially respond to increasing processing demand. Investigation of differences in neuronal activation, however, has been complicated by methodological inconsistencies and concomitant discrepancies in degree of difficulty and subject effort between disparate tasks. In this study, we utilized fMRI to compare neural activation patterns associated with two related attention tasks associated with different degrees of processing load while controlling for degree of performance difficulty. Healthy volunteers performed two continuous performance tasks, utilizing an identical pairs paradigm (CPT-IP) and a matched simple number recognition paradigm with degraded stimuli (CPT-DS) during a single fMRI scan. Degree of stimulus resolution degradation in the latter CPT was designed to equalize degree of performancedifficulty between the two tasks. CPT-IP and CPT-DS were both associated with activation of frontal, limbic, subcortical, and sensory integratory structures. CPT-IP administration was associated with significantly greater activation of left dorsolateral prefrontal cortex, bilateral posterior temporal cortex, bilateral putamen, and thalamus. This study demonstrates both that differing attention tasks are associated with a high degree of functional overlap and that increasing processing demand is associated with increased activation of specific portions of attentional networks. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 21/01/20 alle ore 01:40:18